DNA methylation occurs at cytosines, predominantly in the CpG dinucleotide context and is
a key epigenetic regulator of embryogenesis and stem-cell differentiation in mammals. The …

Cytosine methylation is an epigenetically propagated DNA modification that can modify how
the DNA molecule is recognized and expressed. DNA methylation undergoes extensive …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

From a fertilised egg to a mature organism, cells divide and accumulate epigenetic
information, which is faithfully passed on to daughter cells. DNA methylation consolidates …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

The epigenomes of early mammalian embryos are extensively reprogrammed to acquire a
totipotent developmental potential. A major initial event in this reprogramming is the active …

DNA modification, methylation of cytosine (5mC), and oxidation of 5mC to 5-
hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) can …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

In mammals, DNA methylation and hydroxymethylation are specific epigenetic mechanisms
that can contribute to the regulation of gene expression and cellular functions. DNA …

Epigenetic reprogramming involves processes that lead to the erasure of epigenetic
information, reverting the chromatin template to a less differentiated state. Extensive …