Cytosine methylation in mammals is an epigenetic modification required for viability of the
developing embryo. It has been suggested that DNA methylation plays important roles in X …

DNA methylation plays important roles during development. However, the DNA methylation
reprogramming of functional elements has not been fully investigated during mammalian …

Genes constitute only a small proportion of the mammalian genome, the majority of which is
composed of non-genic repetitive elements including interspersed repeats and satellites. A …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

DNA methylation in the form of 5-methylcytosine (5mC) is a key epigenetic regulator in
mammals, and the dynamic balance between methylation and demethylation impacts …

DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …

Methylation of the base cytosine in DNA is critical for silencing endogenous retroviruses,
regulating gene expression, and establishing cellular identity, and has long been regarded …

DNA methylation, an epigenetic mechanism is claimed to play essential roles in
development, aging and disease over the past few decades. Cytosines (C) were known to …

Background DNA methylation (5mC) plays important roles in epigenetic regulation of
genome function. Recently, TET hydroxylases have been found to oxidise 5mC to …

The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …