DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning
Recent technological advances have enabled DNA methylation to be assayed at single-cell
resolution. However, current protocols are limited by incomplete CpG coverage and hence …
resolution. However, current protocols are limited by incomplete CpG coverage and hence …
Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements
Background Recent assays for individual-specific genome-wide DNA methylation profiles
have enabled epigenome-wide association studies to identify specific CpG sites associated …
have enabled epigenome-wide association studies to identify specific CpG sites associated …
Whole-genome DNA methylation profiling using MethylCap-seq
AB Brinkman, F Simmer, K Ma, A Kaan, J Zhu… - Methods, 2010 - Elsevier
MethylCap-seq is a robust procedure for genome-wide profiling of DNA methylation. The
approach consists of the capture of methylated DNA using the MBD domain of MeCP2, and …
approach consists of the capture of methylated DNA using the MBD domain of MeCP2, and …
Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
Genomic DNA methylation profiles exhibit substantial variation within the human population,
with important functional implications for gene regulation. So far little is known about the …
with important functional implications for gene regulation. So far little is known about the …
Simultaneous profiling of transcriptome and DNA methylome from a single cell
Background Single-cell transcriptome and single-cell methylome technologies have become
powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide …
powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide …
Combining MeDIP-seq and MRE-seq to investigate genome-wide CpG methylation
DNA CpG methylation is a widespread epigenetic mark in high eukaryotes including
mammals. DNA methylation plays key roles in diverse biological processes such as X …
mammals. DNA methylation plays key roles in diverse biological processes such as X …
Cytosine methylation profiling of cancer cell lines
DNA-methylation changes in human cancer are complex and vary between the different
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
Profiling genome-wide DNA methylation
DNA methylation is an epigenetic modification that plays an important role in regulating
gene expression and therefore a broad range of biological processes and diseases. DNA …
gene expression and therefore a broad range of biological processes and diseases. DNA …
Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias, and copy number variation
DNA methylation is an essential epigenetic modification that plays a key role associated with
the regulation of gene expression during differentiation, but in disease states such as …
the regulation of gene expression during differentiation, but in disease states such as …
High-throughput robust single-cell DNA methylation profiling with sciMETv2
DNA methylation is a key epigenetic property that drives gene regulatory programs in
development and disease. Current single-cell methods that produce high quality …
development and disease. Current single-cell methods that produce high quality …
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