Structural and functional specificity of H3K36 methylation
The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic
stability. Indeed, this methylation mark is essential for proper transcription, recombination …
stability. Indeed, this methylation mark is essential for proper transcription, recombination …
Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation
Histone H3 lysine 36 methylation (H3K36me) is critical for epigenetic regulation and
mutations at or near H3K36 are associated with distinct types of cancers. H3K36M …
mutations at or near H3K36 are associated with distinct types of cancers. H3K36M …
Understanding histone H3 lysine 36 methylation and its deregulation in disease
Methylation of histone H3 lysine 36 (H3K36) plays crucial roles in the partitioning of
chromatin to distinctive domains and the regulation of a wide range of biological processes …
chromatin to distinctive domains and the regulation of a wide range of biological processes …
Understanding the language of Lys36 methylation at histone H3
EJ Wagner, PB Carpenter - Nature reviews Molecular cell biology, 2012 - nature.com
Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …
histone H3 (H3K36). Several enzymes from yeast and humans, including the …
[PDF][PDF] Unique and shared roles for histone H3K36 methylation states in transcription regulation functions
Set2 co-transcriptionally methylates lysine 36 of histone H3 (H3K36), producing mono-, di-,
and trimethylation (H3K36me1/2/3). These modifications recruit or repel chromatin effector …
and trimethylation (H3K36me1/2/3). These modifications recruit or repel chromatin effector …
Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction
Somatic mutations on glycine 34 of histone H3 (H3G34) cause pediatric cancers, but the
underlying oncogenic mechanism remains unknown. We demonstrate that substituting …
underlying oncogenic mechanism remains unknown. We demonstrate that substituting …
Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4
HN Du, IM Fingerman, SD Briggs - Genes & development, 2008 - genesdev.cshlp.org
Set2-mediated H3 K36 methylation is an important histone modification on chromatin during
transcription elongation. Although Set2 associates with the phosphorylated C-terminal …
transcription elongation. Although Set2 associates with the phosphorylated C-terminal …
Nucleosome and ubiquitin position Set2 to methylate H3K36
S Bilokapic, M Halic - Nature Communications, 2019 - nature.com
Histone H3 lysine 36 methylation (H3K36me) is a conserved histone modification deposited
by the Set2 methyltransferases. Recent findings show that over-expression or mutation of …
by the Set2 methyltransferases. Recent findings show that over-expression or mutation of …
Degrees make all the difference: the multifunctionality of histone H4 lysine 20 methylation
Y Wang, S Jia - Epigenetics, 2009 - Taylor & Francis
Residue and degree-specific methylation of histone lysines along with other epigenetic
modifications organizes chromatin into distinct domains and regulates almost every aspect …
modifications organizes chromatin into distinct domains and regulates almost every aspect …
Decoding the histone H4 lysine 20 methylation mark
L Balakrishnan, B Milavetz - Critical reviews in biochemistry and …, 2010 - Taylor & Francis
The molecular biology of histone H4 lysine 20 (H4K20) methylation, like many other post-
translational modifications of histones, has been the subject of intensive interest in recent …
translational modifications of histones, has been the subject of intensive interest in recent …