DNMT3A in haematological malignancies
L Yang, R Rau, MA Goodell - Nature Reviews Cancer, 2015 - nature.com
DNA methylation patterns are disrupted in various malignancies, suggesting a role in the
development of cancer, but genetic aberrations directly linking the DNA methylation …
development of cancer, but genetic aberrations directly linking the DNA methylation …
DNMT3A in Leukemia
L Brunetti, MC Gundry… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
DNA methylation is an epigenetic process involved in development, aging, and cancer.
Although the advent of new molecular techniques has enhanced our knowledge of how …
Although the advent of new molecular techniques has enhanced our knowledge of how …
[HTML][HTML] Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies
CB Cole, DA Russler-Germain, S Ketkar… - The Journal of …, 2017 - Am Soc Clin Investig
The gene that encodes de novo DNA methyltransferase 3A (DNMT3A) is frequently mutated
in acute myeloid leukemia genomes. Point mutations at position R882 have been shown to …
in acute myeloid leukemia genomes. Point mutations at position R882 have been shown to …
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
SJ Kim, H Zhao, S Hardikar, AK Singh… - Blood, The Journal …, 2013 - ashpublications.org
Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur
frequently in acute myeloid leukemia and other hematological malignancies, with the …
frequently in acute myeloid leukemia and other hematological malignancies, with the …
[HTML][HTML] Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by …
JE Sandoval, YH Huang, A Muise, MA Goodell… - Journal of Biological …, 2019 - ASBMB
Eukaryotic DNA methylation prevents genomic instability by regulating the expression of
oncogenes and tumor-suppressor genes. The negative effects of dysregulated DNA …
oncogenes and tumor-suppressor genes. The negative effects of dysregulated DNA …
DNA methyltransferases in hematological malignancies
DNA methyltransferases (DNMTs) are an evolutionarily conserved family of DNA
methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The …
methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The …
[HTML][HTML] Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation
C Holz-Schietinger, DM Matje, NO Reich - Journal of Biological Chemistry, 2012 - ASBMB
DNA methylation is a key regulator of gene expression and changes in DNA methylation
occur early in tumorigenesis. Mutations in the de novo DNA methyltransferase gene …
occur early in tumorigenesis. Mutations in the de novo DNA methyltransferase gene …
DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells
J Xu, YY Wang, YJ Dai, W Zhang… - Proceedings of the …, 2014 - National Acad Sciences
The gene encoding DNA methyltransferase 3A (DNMT3A) is mutated in∼ 20% of acute
myeloid leukemia cases, with Arg882 (R882) as the hotspot. Here, we addressed the …
myeloid leukemia cases, with Arg882 (R882) as the hotspot. Here, we addressed the …
Structural basis for DNMT3A-mediated de novo DNA methylation
DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at
cytosines is essential for genome regulation and development,. Dysregulation of this …
cytosines is essential for genome regulation and development,. Dysregulation of this …
[HTML][HTML] CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression
DNMT3A mutations occur in∼ 25% of acute myeloid leukemia (AML) patients. The most
common mutation, DNMT3A R882H, has dominant negative activity that reduces DNA …
common mutation, DNMT3A R882H, has dominant negative activity that reduces DNA …