Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

One of the most fundamental questions in the control of gene expression in mammals is how
epigenetic methylation patterns of DNA and histones are established, erased, and …

Genetic, biochemical and cytological studies on DNA methylation in several eukaryotic
organisms have resulted in leaps of understanding in the past three years. Discoveries of …

Methylation of cytosines can mediate epigenetic gene silencing and is the only known DNA
modification in eukaryotes. Recent efforts to map DNA methylation across mammalian …

Histone methylation has important roles in regulating transcription, genome integrity and
epigenetic inheritance. Historically, methylated histone arginine and lysine residues have …

DNA methylation, histone deacetylation, and methylation of histone H3 at lysine 9 are the
three best-characterized covalent modifications associated with a repressed chromatin state …

Post-translational addition of methyl groups to the amino-terminal tails of histone proteins
was discovered more than three decades ago. Only now, however, is the biological …

DNA methylation is important in the control of gene transcription and chromatin structure.
The complexities of this process are just beginning to be elucidated in relationship to other …

One of the most fundamental questions in the control of gene expression in mammals is how
epigenetic methylation patterns of DNA and histones are established, erased, and …

Histone lysine methylation and DNA methylation contribute to transcriptional regulation. We
have previously shown that acetylated histones are associated with unmethylated DNA and …