The fungal pathogen Cryptococcus neoformans is a major cause of illness in
immunocompromised individuals such as AIDS patients. The ability of the fungus to acquire …

The level of available iron in the mammalian host is extremely low, and pathogenic microbes
must compete with host proteins such as transferrin for iron. Iron regulation of gene …

Cryptococcus neoformans is the leading cause of fungal meningitis in humans. Production
of a polysaccharide capsule is a key virulence property for the fungus and capsule synthesis …

Iron overload is known to exacerbate many infectious diseases, and conversely, iron
withholding is an important defense strategy for mammalian hosts. Iron is a critical cue for …

The acquisition of iron and the maintenance of iron homeostasis are important aspects of
virulence for the pathogenic fungus Cryptococcus neoformans. In this study, we …

Balance of physiological levels of iron is essential for every organism. In Aspergillus
fumigatus and other fungal pathogens, the transcription factor HapX mediates adaptation to …

Iron acquisition is a critical aspect of the virulence of many pathogenic microbes, and iron
limitation is an important defense mechanism for mammalian hosts. We are examining …

Iron acquisition is critical for virulence of the human pathogenic fungus Cryptococcus
neoformans. The cryptococcal transcript for the extracellular mannoprotein Cig1 is highly …

The mechanisms by which pathogens sense and transport iron are important during
infection, because of the low availability of free iron in the mammalian host. Iron is a key …

Vertebrate hosts actively sequester iron, and fungal and other pathogens must therefore
adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that …