Upon Cryptococcus neoformans infection of the host lung, the fungus enters a nutrient poor
environment and must adapt to a variety of host-specific stress conditions (temperature …

Highlights•Heme can be used as iron source in saprophytic and parasitic fungi.•Parasitic
fungi can utilize heme from blood hemoglobin.•C. albicans secretes hemophores of the …

Highlights•Abc3 functions in the transport of vacuolar iron stores.•When iron is abundant,
Fep1 represses genes involved in iron acquisition.•Grx4 is an inhibitory binding partner of …

Previous studies have implicated ferric reduction in the iron uptake pathway of the
opportunistic pathogen Cryptococcus neoformans. Here we studied iron uptake directly …

Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …

Siderophores are small organic compounds with high affinity for ferric iron. Microorganisms
commonly acquire iron via siderophore secretion and uptake. Here we report the …

All living organisms require certain micronutrients such as iron, zinc, manganese and
copper for cellular function and growth. For human pathogens however, the maintenance of …

Iron is an essential metal for virtually all organisms. Iron acquisition is well characterized for
various organisms, whereas intracellular iron distribution is poorly understood. In contrast to …

The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among
HIV-infected individuals. We utilized the completed genome sequence and optimized …

Iron homeostasis is highly regulated in organisms across evolutionary time scale as iron is
essential for various cellular processes. In a computational screen, we identified the …