The character of a cell is defined by its constituent proteins, which are the result of specific
patterns of gene expression. Crucial determinants of gene expression patterns are DNA …

It has been nearly 40 y since it was suggested that genomic methylation patterns could be
transmitted via maintenance methylation during S phase and might play a role in the …

Genes are essential for the transmission of genetic information from generation to
generation, and this mechanism of inheritance is fully understood. Genes are also essential …

A large number of studies have documented the methylation patterns of individual genes
and repeated sequences in different tissues of various mammalian species. This has …

Proper establishment and faithful maintenance of epigenetic information is crucial for the
correct development of complex organisms. For mammals, it is now accepted that DNA …

We have developed a strategy to distinguish between the methylation patterns of
homologous chromosomes in tissues, and to follow these patterns in human pedigrees. This …

Several lines of evidence strongly suggest that DNA methylation is involved in embryo
development. Perhaps the most direct evidence comes from experiments with …

Mammalian cellular differen-tiation and development depend on stable, somatically
heritable epigenetic switches. A good example is X chromosome inactivation, the random …

Mammalian development requires cytosine methylation, a heritable epigenetic mark of
cellular memory believed to maintain a cell's unique gene expression pattern. However, it …

Classical genetics has revealed the mechanisms for the transmission of genes from
generation to generation, but the strategy of the genes in unfolding the developmental …