The distribution of 5-methylcytosine (m5C) in vertebrate genomes is strikingly different from
that in all other animal genomes that have been examined. In the vertebrates, almost all …

The DNA MTase gene was disrupted by homologous recombination as described previously
(Li et al. 1992). The targeting vector contained a 900-bp deletion extending from the NaeI …

An obstacle to progress in understanding eukaryotic DNA methylation has been the lack of a
good genetic systemthe most favorable eukaryotes for genetic analysis (yeasts …

Methylation of cytosines can mediate epigenetic gene silencing and is the only known DNA
modification in eukaryotes. Recent efforts to map DNA methylation across mammalian …

DNA methylation represents a form of genome annotation that mediates gene repression by
serving as a maintainable mark that can be used to reconstruct silent chromatin following …

In the first half of the twentieth century, developmental biology and genetics were separate
disciplines. The word epigenetics was coined by Waddington to link the two fields …

DNA methylation inhibits gene expression in animal cells, probably by affecting chromatin
structure. Biochemical studies suggest that this process may be mediated by methyl-specific …

In this review, we will provide a brief reminder of epigenetic phenomena in general, and
DNA methylation in particular. We will then underline the characteristics of the in vivo …

DNA methylation is a key epigenetic modification in the vertebrate genomes known to be
involved in biological processes such as regulation of gene expression, DNA structure and …

DNA in somatic tissue is characterized by a bimodal pattern of methylation, which is
established in the animal through a series of developmental events 1. In the mouse blastula …