Despite thousands of articles about 5-methylcytosine (m5C) residues in vertebrate DNA,
there is still controversy concerning the role of genomic m5C in normal vertebrate …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

Methylation patterns of specific genes have been studied by polymerase chain reaction and
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are …

It has long been held that reversible promoter methylation allows genes to be expressed in
the appropriate cell types during development. However, no endogenous gene has been …

Epigenetics refers to mitotically and/or meiotically heritable variations in gene expression
that are not caused by changes in DNA sequence. Epigenetic mechanisms regulate all …

Recent advances have expanded our understanding of the processes underlying the
establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes …

The biological significance of 5-methylcytosine was in doubt for many years, but is no
longer. Through targeted mutagenesis in mice it has been learnt that every protein shown by …

This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …

In mammals the genome is shaped by epigenetic regulation to manifest numerous cellular
identities. The term epigenetics has been used to refer to changes in gene expression …

Methylation of DNA, which occurs at cytosines of CpG sequences, is a unique chemical
modification of the vertebrate genome. Methylation patterns can be copied to daughter DNA …