DNA methylation is an epigenetic mark involved in regulating genome function and is critical
for normal development in mammals. It has been observed that the developmental …

DNA methylation plays important roles during development. However, the DNA methylation
reprogramming of functional elements has not been fully investigated during mammalian …

Nuclear transfer experiments have demonstrated that epigenetic mechanisms operate to
limit gene expression during animal development. In somatic cells, silenced genes are …

The above experiments support a relatively simple model to explain the role of DNA
methylation in vivo. Most tissue-specific genes are methylated. The methyl groups may …

Epigenetics plays an important role in orchestrating key biologic processes. Epigenetic
marks, including DNA methylation, histones, chromatin structure, and noncoding RNAs, are …

The role of DNA methylation in brain development is an intense area of research because
the brain has particularly high levels of CpG and mutations in many of the proteins involved …

A large body of evidence demonstrates that DNA methylation plays a role in gene regulation
in animal cells. Not only is there a correlation between gene transcription and …

Methyl-accepting assays and a sensitive method for labeling specific CpG sites have been
used to show that the DNA of F9 embryonal carcinoma cells decreases in 5-methylcytosine …

DNA methylation is an epigenetic modification which plays an important role in chromatin
organization and gene expression. DNA methylation can silence genes and repetitive …

The ability to form memories is a prerequisite for an organism's behavioral adaptation to
environmental changes. At the molecular level, the acquisition and maintenance of memory …