DNA methylation patterns in genome are maintained during replication by a DNA
methyltransferase Dnmt1. Mouse Dnmt1 is a 180 kDa protein comprising the N-terminal …

The mammalian DNA methyltransferase Dnmt1 is responsible for the maintenance of the
pattern of DNA methylation in vivo. It is a large multidomain enzyme comprising 1620 amino …

DNMT2 is a human protein that displays strong sequence similarities to DNA (cytosine-5)-
methyltransferases (m5C MTases) of both prokaryotes and eukaryotes. DNMT2 contains all …

Background In mammals, epigenetic information is established and maintained via the
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …

DNA methylation is a major epigenetic modification and plays a crucial role in the regulation
of gene expression. Within the family of DNA methyltransferases (Dnmts), Dnmt3a and 3b …

In mammalian cells, DNA methylation patterns are precisely maintained after DNA
replication with defined changes occurring during development. The major DNA …

The Dnmt3a gene, which encodes de novo-type DNA methyltransferase, encodes two
isoforms, full-length Dnmt3a and Dnmt3a2, which lacks the N-terminal 219 amino acid …

Dnmt1 is the predominant DNA methyltransferase (MTase) in mammals. The C-terminal
domain of Dnmt1 clearly shares sequence similarity with many prokaryotic 5mC …

Abstract DNMT1 (DNA methyltransferase 1) is responsible for propagating the DNA
methylation patterns during DNA replication. DNMT1 contains, in addition to a C-terminal …

We present the first in vitro study investigating the catalytic properties of a mammalian de
novo DNA methyltransferase. Dnmt3a from mouse was cloned and expressed in …