Significance: Methylation of cytosine in DNA is linked with gene regulation, and this has
profound implications in development, normal biology, and disease conditions in many …

With the rapid development of genome-wide high-throughput technologies, including
expression arrays, SNP arrays and next-generation sequencing platforms, enormous …

DNA cytosine methylation is a central epigenetic modification which plays critical roles in
cellular processes including genome regulation, development and disease. Here, we review …

DNA methylation plays a key role in regulating eukaryotic gene expression. Although
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …

Genomic DNA methylation profiles exhibit substantial variation within the human population,
with important functional implications for gene regulation. So far little is known about the …

Cytosine methylation is the most common covalent modification of DNA in eukaryotes. DNA
methylation has an important role in many aspects of biology, including development and …

Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …

In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

Background DNA methylation is an epigenetic modification that is studied at a single-base
resolution with bisulfite treatment followed by high-throughput sequencing. After alignment …

DNA methylation is an important epigenetic modification for genomic regulation in higher
organisms that plays a crucial role in the initiation and progression of diseases. The …