Pharmacokinetics of midazolam in critically ill neonates
E Jacqz-Aigrain, C Wood, I Robieux - European journal of clinical …, 1990 - Springer
Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and
children. An IV bolus of midazolam 0.2 mg· kg− 1 was administered to 10 critically ill …
children. An IV bolus of midazolam 0.2 mg· kg− 1 was administered to 10 critically ill …
Pharmacokinetics of midazolam during continuous infusion in critically ill neonates
E Jacqz-Aigrain, P Daoud, P Burtin, S Maherzi… - European journal of …, 1992 - Springer
Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and
children. An IV bolus (0.2 mg· kg− 1) immediately followed by continuous infusion of 0.06 …
children. An IV bolus (0.2 mg· kg− 1) immediately followed by continuous infusion of 0.06 …
Pharmacokinetics and metabolism of intravenous midazolam in preterm infants
SN De Wildt, GL Kearns, WCJ Hop… - Clinical …, 2001 - Wiley Online Library
Background Midazolam, a benzodiazepine, is finding expanded use in neonatal intensive
care units. We studied the pharmacokinetics and metabolism of midazolam after a single …
care units. We studied the pharmacokinetics and metabolism of midazolam after a single …
Clinical pharmacology of midazolam in infants and children
JL Blumer - Clinical pharmacokinetics, 1998 - Springer
Midazolam is a parenteral benzodiazepine with sedative, amnesic, anxiolytic, muscle
relaxant and anticonvulsant properties. The drug exerts its clinical effect by binding to a …
relaxant and anticonvulsant properties. The drug exerts its clinical effect by binding to a …
Haemodynamic responses and population pharmacokinetics of midazolam following administration to ventilated, preterm neonates
GJ Harte, PH Gray, TC Lee, PA Steer… - Journal of paediatrics …, 1997 - Wiley Online Library
Objective: To evaluate the effects of intravenous midazolam on haemodynamic variables
and cerebral blood flow velocity (CBFV) and to determine the pharmacokinetics using a …
and cerebral blood flow velocity (CBFV) and to determine the pharmacokinetics using a …
Clinical pharmacology of midazolam in neonates and children: effect of disease—a review
GM Pacifici - International journal of pediatrics, 2014 - Wiley Online Library
Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In
healthy neonates the half‐life (t1/2) and the clearance (Cl) are 3.3‐fold longer and 3.7‐fold …
healthy neonates the half‐life (t1/2) and the clearance (Cl) are 3.3‐fold longer and 3.7‐fold …
Population pharmacokinetics of midazolam in neonates
P Burtin, E Jacqz‐Aigrain, P Girard… - Clinical …, 1994 - Wiley Online Library
Objective To describe the pharmacokinetics of midazolam, a water‐soluble benzodiazepine
with a short half‐life, in critically ill neonates. Hypothesis Midazolam clearance is reduced in …
with a short half‐life, in critically ill neonates. Hypothesis Midazolam clearance is reduced in …
Steady-state plasma concentrations of midazolam in critically ill infants and children
J Hughes, AM Gill, H Mulhearn… - Annals of …, 1996 - journals.sagepub.com
OBJECTIVE: To determine the steady-state plasma concentrations of midazolam in critically
ill infants and children. DESIGN: Prospective uncontrolled study conducted over 18 months …
ill infants and children. DESIGN: Prospective uncontrolled study conducted over 18 months …
The pharmacokinetics of midazolam in paediatric patients
K Payne, FJ Mattheyse, D Liebenberg… - European journal of …, 1989 - Springer
A serum concentration profile study on midazolam in children was done. Fifty six children
aged 3–10 years took part. The routes investigated were intravenous, intramuscular, rectal …
aged 3–10 years took part. The routes investigated were intravenous, intramuscular, rectal …
The use of midazolam in the preterm neonate
J van den Anker, P Sauer - European journal of pediatrics, 1992 - repub.eur.nl
Sir: Numerous recent reports have demonstrated the occurrence of pain and stress and their
many effects in critically ill neonates. They emphasize the importance of analgesia and …
many effects in critically ill neonates. They emphasize the importance of analgesia and …
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