Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus

M Jeffries, M Dozmorov, Y Tang, JT Merrill, JD Wren… - Epigenetics, 2011 - Taylor & Francis
Systemic lupus erythematosus is a chronic-relapsing autoimmune disease of incompletely
understood etiology. Recent evidence strongly supports an epigenetic contribution to the …

Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus …

P Coit, M Jeffries, N Altorok, MG Dozmorov… - Journal of …, 2013 - Elsevier
Systemic lupus erythematosus is an autoimmune disease characterized by multi-system
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …

Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ …

DM Absher, X Li, LL Waite, A Gibson, K Roberts… - PLoS …, 2013 - journals.plos.org
Systemic lupus erythematosus (SLE) is an autoimmune disease with known genetic,
epigenetic, and environmental risk factors. To assess the role of DNA methylation in SLE, we …

Impaired DNA methylation and its mechanisms in CD4+ T cells of systemic lupus erythematosus

Y Zhang, M Zhao, AH Sawalha, B Richardson… - Journal of autoimmunity, 2013 - Elsevier
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by
production of autoantibodies against a series of nuclear antigens. Although the exact cause …

Renal involvement in lupus is characterized by unique DNA methylation changes in naïve CD4+ T cells

P Coit, P Renauer, MA Jeffries, JT Merrill… - Journal of …, 2015 - Elsevier
Systemic lupus erythematosus is a multi-system disease characterized by wide-spread DNA
methylation changes. To identify epigenetic susceptibility loci for lupus nephritis, genome …

DNA methylation in systemic lupus erythematosus

CM Hedrich, K Mäbert, T Rauen, GC Tsokos - Epigenomics, 2017 - Taylor & Francis
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by
aberrant immune responses directed against cells and tissues, resulting in inflammation and …

Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils

P Coit, S Yalavarthi, M Ognenovski, W Zhao… - Journal of …, 2015 - Elsevier
Recent evidence suggests that neutrophils play an important role in the pathogenesis of
lupus. The goal of this study was to characterize the epigenetic architecture, by studying the …

Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: identifying DNA methylation signatures associated with …

S Joseph, NI George, B Green-Knox, EL Treadwell… - Journal of …, 2019 - Elsevier
Systemic lupus erythematosus (SLE or lupus) is a heterogeneous autoimmune disease
characterized by the involvement of multiple organs and the production of antinuclear …

Genome-wide assessment of differential DNA methylation associated with autoantibody production in systemic lupus erythematosus

SA Chung, J Nititham, E Elboudwarej, HL Quach… - PloS one, 2015 - journals.plos.org
Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies
associated with specific clinical manifestations. Previous studies have shown an association …

Epigenetic variability in systemic lupus erythematosus: what we learned from genome-wide DNA methylation studies

M Teruel, AH Sawalha - Current rheumatology reports, 2017 - Springer
Purpose of Review DNA methylation has emerged as an important contributing factor in the
pathogenesis of systemic lupus erythematosus (SLE). Here, we describe the DNA …