Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus
Systemic lupus erythematosus is a chronic-relapsing autoimmune disease of incompletely
understood etiology. Recent evidence strongly supports an epigenetic contribution to the …
understood etiology. Recent evidence strongly supports an epigenetic contribution to the …
Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus …
Systemic lupus erythematosus is an autoimmune disease characterized by multi-system
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …
Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ …
DM Absher, X Li, LL Waite, A Gibson, K Roberts… - PLoS …, 2013 - journals.plos.org
Systemic lupus erythematosus (SLE) is an autoimmune disease with known genetic,
epigenetic, and environmental risk factors. To assess the role of DNA methylation in SLE, we …
epigenetic, and environmental risk factors. To assess the role of DNA methylation in SLE, we …
Impaired DNA methylation and its mechanisms in CD4+ T cells of systemic lupus erythematosus
Y Zhang, M Zhao, AH Sawalha, B Richardson… - Journal of autoimmunity, 2013 - Elsevier
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by
production of autoantibodies against a series of nuclear antigens. Although the exact cause …
production of autoantibodies against a series of nuclear antigens. Although the exact cause …
Renal involvement in lupus is characterized by unique DNA methylation changes in naïve CD4+ T cells
P Coit, P Renauer, MA Jeffries, JT Merrill… - Journal of …, 2015 - Elsevier
Systemic lupus erythematosus is a multi-system disease characterized by wide-spread DNA
methylation changes. To identify epigenetic susceptibility loci for lupus nephritis, genome …
methylation changes. To identify epigenetic susceptibility loci for lupus nephritis, genome …
DNA methylation in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by
aberrant immune responses directed against cells and tissues, resulting in inflammation and …
aberrant immune responses directed against cells and tissues, resulting in inflammation and …
Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils
P Coit, S Yalavarthi, M Ognenovski, W Zhao… - Journal of …, 2015 - Elsevier
Recent evidence suggests that neutrophils play an important role in the pathogenesis of
lupus. The goal of this study was to characterize the epigenetic architecture, by studying the …
lupus. The goal of this study was to characterize the epigenetic architecture, by studying the …
Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: identifying DNA methylation signatures associated with …
S Joseph, NI George, B Green-Knox, EL Treadwell… - Journal of …, 2019 - Elsevier
Systemic lupus erythematosus (SLE or lupus) is a heterogeneous autoimmune disease
characterized by the involvement of multiple organs and the production of antinuclear …
characterized by the involvement of multiple organs and the production of antinuclear …
Genome-wide assessment of differential DNA methylation associated with autoantibody production in systemic lupus erythematosus
SA Chung, J Nititham, E Elboudwarej, HL Quach… - PloS one, 2015 - journals.plos.org
Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies
associated with specific clinical manifestations. Previous studies have shown an association …
associated with specific clinical manifestations. Previous studies have shown an association …
Epigenetic variability in systemic lupus erythematosus: what we learned from genome-wide DNA methylation studies
M Teruel, AH Sawalha - Current rheumatology reports, 2017 - Springer
Purpose of Review DNA methylation has emerged as an important contributing factor in the
pathogenesis of systemic lupus erythematosus (SLE). Here, we describe the DNA …
pathogenesis of systemic lupus erythematosus (SLE). Here, we describe the DNA …
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