While the human genome sequence is relatively uniform between the cells of an individual,
the DNA methylation of the genome (methylome) has unique features in different cells …

Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also
over larger genomic regions. In most human tissues, the vast majority of the genome is …

Epigenetic modifications, and particularly DNA methylation, have been studied in many
tissues, both healthy and diseased, and across numerous developmental stages. The …

Over the last 20-80 million years the mammalian placenta has taken on a variety of
morphologies through both divergent and convergent evolution. Recently we have shown …

Methylation of DNA, which occurs at cytosines of CpG sequences, is a unique chemical
modification of the vertebrate genome. Methylation patterns can be copied to daughter DNA …

Epigenetic processes, such as DNA methylation, are known to regulate tissue specific gene
expression. We explored this concept in the placenta to define whether DNA methylation is …

The placenta is a fetal exchange organ connecting mother and baby that facilitates fetal
growth in utero. DNA methylation is thought to impact placental development and function …

This review provides an overview of the unique features of DNA methylation in the human
placenta. We discuss the importance of understanding placental development, structure …

Although male–female differences in placental structure and function have been observed,
little is understood about their molecular underpinnings. Here, we present a mega-analysis …

The majority of congenital heart defects (CHDs) are thought to result from the interaction
between multiple genetic, epigenetic, environmental, and lifestyle factors. Epigenetic …