How has the study of the human placenta aided our understanding of partially methylated genes?
DI Schroeder, JM LaSalle - Epigenomics, 2013 - Taylor & Francis
While the human genome sequence is relatively uniform between the cells of an individual,
the DNA methylation of the genome (methylome) has unique features in different cells …
the DNA methylation of the genome (methylome) has unique features in different cells …
The human placenta methylome
DI Schroeder, JD Blair, P Lott, HOK Yu… - Proceedings of the …, 2013 - National Acad Sciences
Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also
over larger genomic regions. In most human tissues, the vast majority of the genome is …
over larger genomic regions. In most human tissues, the vast majority of the genome is …
[HTML][HTML] Recent progress towards understanding the role of DNA methylation in human placental development
Epigenetic modifications, and particularly DNA methylation, have been studied in many
tissues, both healthy and diseased, and across numerous developmental stages. The …
tissues, both healthy and diseased, and across numerous developmental stages. The …
[HTML][HTML] Early developmental and evolutionary origins of gene body DNA methylation patterns in mammalian placentas
DI Schroeder, K Jayashankar, KC Douglas… - PLoS …, 2015 - journals.plos.org
Over the last 20-80 million years the mammalian placenta has taken on a variety of
morphologies through both divergent and convergent evolution. Recently we have shown …
morphologies through both divergent and convergent evolution. Recently we have shown …
Epigenetics: the DNA methylation profile of tissue-dependent and differentially methylated regions in cells
J Ohgane, S Yagi, K Shiota - Placenta, 2008 - Elsevier
Methylation of DNA, which occurs at cytosines of CpG sequences, is a unique chemical
modification of the vertebrate genome. Methylation patterns can be copied to daughter DNA …
modification of the vertebrate genome. Methylation patterns can be copied to daughter DNA …
Cell specific patterns of methylation in the human placenta
A Grigoriu, JC Ferreira, S Choufani, D Baczyk… - Epigenetics, 2011 - Taylor & Francis
Epigenetic processes, such as DNA methylation, are known to regulate tissue specific gene
expression. We explored this concept in the placenta to define whether DNA methylation is …
expression. We explored this concept in the placenta to define whether DNA methylation is …
Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation
TKJB Gamage, W Schierding, P Tsai… - Biology …, 2018 - journals.biologists.com
The placenta is a fetal exchange organ connecting mother and baby that facilitates fetal
growth in utero. DNA methylation is thought to impact placental development and function …
growth in utero. DNA methylation is thought to impact placental development and function …
The human placental methylome
WP Robinson, EM Price - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
This review provides an overview of the unique features of DNA methylation in the human
placenta. We discuss the importance of understanding placental development, structure …
placenta. We discuss the importance of understanding placental development, structure …
[HTML][HTML] Large-scale placenta DNA methylation integrated analysis reveals fetal sex-specific differentially methylated CpG sites and regions
SV Andrews, IJ Yang, K Froehlich, T Oskotsky… - Scientific reports, 2022 - nature.com
Although male–female differences in placental structure and function have been observed,
little is understood about their molecular underpinnings. Here, we present a mega-analysis …
little is understood about their molecular underpinnings. Here, we present a mega-analysis …
[HTML][HTML] Maternal genome-wide DNA methylation patterns and congenital heart defects
S Chowdhury, SW Erickson, SL MacLeod, MA Cleves… - PloS one, 2011 - journals.plos.org
The majority of congenital heart defects (CHDs) are thought to result from the interaction
between multiple genetic, epigenetic, environmental, and lifestyle factors. Epigenetic …
between multiple genetic, epigenetic, environmental, and lifestyle factors. Epigenetic …