Melatonin is a fascinating molecule that has captured the imagination of many scientists
since its discovery in 1958. In recent times, the focus has changed from investigating its …

During the last 20 years, numerous clinical trials have examined the therapeutic usefulness
of melatonin in different fields of medicine. The objective of this article is to review, in depth …

Highlights•Pathways controlling melatonin secretion are complex.•There are various causes
of melatonin disturbance.•Evaluation of melatonin secretion clinically requires long time …

Melatonin: Biosynthesis, Physiological Effects, and Clinical Applications provides a thorough
review of recent advances in major areas of melatonin research. The book is arranged in a …

Melatonin was discovered more than 60 years ago. Since then, several seminal discoveries
have allowed us to define its function as a neuroendocrine hormone and its molecular …

Objectives: Explain the mechanism of action of melatonin. Identify the indications where
exogenous melatonin might prove beneficial. Review the potential adverse effects of …

The functional versatility and diversity of melatonin has exceeded everyone's expectations.
The evidence is substantial that melatonin has multiple receptor-mediated and receptor …

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity
occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including …

Much has been said lately in the lay press about melatonin (Fig. l), the hormone secreted at
night from the pineal gland. Science correspondents and even business page reports have …

Would you believe that something could: Extend your youth by more than ten years? Boost
your immune system in two weeks' time? Help prevent heart disease, Alzheimer's …