Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Abdominal aortic aneurysm: novel mechanisms and therapies

FM Davis, DL Rateri, A Daugherty - Current opinion in cardiology, 2015 - journals.lww.com
Abdominal aortic aneurysm: novel mechanisms and therapies : Current Opinion in
Cardiology Abdominal aortic aneurysm: novel mechanisms and therapies : Current Opinion …

Diagnostic and therapeutic strategies for small abdominal aortic aneurysms

A Klink, F Hyafil, J Rudd, P Faries, V Fuster… - Nature Reviews …, 2011 - nature.com
Abdominal aortic aneurysms (AAA) affect 5% of the population in developed countries and
are characterized by progressive aortic dilatation with an unpredictable time course. This …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

Abdominal aortic aneurysm: evolving controversies and uncertainties

D Carino, TP Sarac, BA Ziganshin… - … Journal of angiology, 2018 - thieme-connect.com
Abdominal aortic aneurysm (AAA) is defined as a permanent dilatation of the abdominal
aorta that exceeds 3 cm. Most AAAs arise in the portion of abdominal aorta distal to the renal …

Pathophysiology and epidemiology of abdominal aortic aneurysms

IM Nordon, RJ Hinchliffe, IM Loftus… - Nature reviews …, 2011 - nature.com
Abdominal aortic aneurysms (AAAs) are found in up to 8% of men aged> 65 years, yet
usually remain asymptomatic until they rupture. Rupture of an AAA and its associated …

Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem

RW Thompson - Current opinion in cardiology, 1996 - journals.lww.com
Abdominal aortic aneurysms (AAAs) are an increasingly common and potentially lethal
condition. Surgical repair of AAA is now yet performed quite safely, yet ruptured AAAs still …

[HTML][HTML] Challenges and opportunities in limiting abdominal aortic aneurysm growth

J Golledge, PE Norman, MP Murphy… - Journal of vascular …, 2017 - Elsevier
Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …

Abdominal aortic aneurysms

N Sakalihasan, JB Michel, A Katsargyris… - Nature reviews Disease …, 2018 - nature.com
An abdominal aortic aneurysm (AAA) is a localized dilatation of the infrarenal aorta. AAA is a
multifactorial disease, and genetic and environmental factors play a part; smoking, male sex …