Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons
DNA methylation is important for controlling gene expression and is catalyzed by DNA
methyltransferase (Dnmt1) an enzyme abundant in brain. We recently demonstrated that …
methyltransferase (Dnmt1) an enzyme abundant in brain. We recently demonstrated that …
[HTML][HTML] DNA modifications and neurological disorders
Mounting evidence has recently underscored the importance of DNA methylation in normal
brain functions. DNA methylation machineries are responsible for dynamic regulation of …
brain functions. DNA methylation machineries are responsible for dynamic regulation of …
DNA-binding factors shape the mouse methylome at distal regulatory regions
Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet
the rules that govern methylation patterns remain largely elusive. To gain insights into this …
the rules that govern methylation patterns remain largely elusive. To gain insights into this …
Dysregulation of schizophrenia-associated genes and genome-wide hypomethylation in neurons overexpressing DNMT1
S Saxena, S Choudhury, PA Maroju, A Anne… - …, 2021 - Taylor & Francis
Aim: To study the effects of DNMT1 overexpression on transcript levels of genes
dysregulated in schizophrenia and on genome-wide methylation patterns. Materials & …
dysregulated in schizophrenia and on genome-wide methylation patterns. Materials & …
The maturing brain methylome
HW Gabel, ME Greenberg - Science, 2013 - science.org
The methylation of DNA in mammalian genomes regulates gene expression, guiding
differentiation and maintaining cellular identity within tissues. However, it may have a distinct …
differentiation and maintaining cellular identity within tissues. However, it may have a distinct …
Spatiotemporal specificity of correlated DNA methylation and gene expression pairs across different human tissues and stages of brain development
ABSTRACT DNA methylation (DNAm) that occurs on promoter regions is primarily
considered to repress gene expression. Previous studies indicated that DNAm could also …
considered to repress gene expression. Previous studies indicated that DNAm could also …
DNA methylation in the developing hippocampus and amygdala of anxiety-prone versus risk-taking rats
RK Simmons, JL Howard, DN Simpson, H Akil… - Developmental …, 2012 - karger.com
All organisms exhibit a wide range of emotional behaviors and interact with the environment
in different ways. Some individuals may be more quiet and shy whereas others are more …
in different ways. Some individuals may be more quiet and shy whereas others are more …
DNA methylation dynamics in health and disease
Y Bergman, H Cedar - Nature structural & molecular biology, 2013 - nature.com
DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …
established at the time of implantation. In this Review, dynamics of DNA methylation during …
Embryonic DNA methylation: insights from the genomics era
O Bogdanović… - Briefings in functional …, 2014 - academic.oup.com
DNA methylation is an epigenetic mark associated with transcriptional repression and
essential for proper vertebrate development. Because of its association with human …
essential for proper vertebrate development. Because of its association with human …
Mutations in human DNA methyltransferase DNMT1 induce specific genome-wide epigenomic and transcriptomic changes in neurodevelopment
Abstract DNA methyltransferase type 1 (DNMT1) is a major enzyme involved in maintaining
the methylation pattern after DNA replication. Mutations in DNMT1 have been associated …
the methylation pattern after DNA replication. Mutations in DNMT1 have been associated …