CG methylation is an epigenetically inherited chemical modification of DNA found in plants
and animals. In mammals it is essential for accurate regulation of gene expression and …

Symmetrical methylation of cytosine residues at CpG dinucleotides of the DNA molecule is a
central epigenetic and heritable hallmark of the genome. This epigenetic modification of …

DNA methylation was the first epigenetic modification discovered. Until recently,
comprehensive coverage of the composition and distribution of methylated cytosines across …

Genetic, biochemical and cytological studies on DNA methylation in several eukaryotic
organisms have resulted in leaps of understanding in the past three years. Discoveries of …

Genomic function is dictated by a combination of DNA sequence and the molecular
mechanisms controlling access to genetic information. Access to DNA can be determined by …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine.
To understand the biological significance of this epigenetic mark it is essential to know …

Background DNA methylation is a major epigenetic modification important for regulating
gene expression and suppressing spurious transcription. Most methods to scan the genome …

DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …

Over three decades ago DNA methylation had been suggested to play a role in the
regulation of gene expression. This chapter reviews the development of this field of research …