Many anecdotal observations exist of a regulatory effect of DNA methylation on gene
expression. However, in general, the underlying mechanisms of this effect are poorly …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

DNA methylation is a heritable and stable epigenetic mark associated with transcriptional
repression. Changes in the patterns and levels of global and regional DNA methylation …

Cytosine methylation is a com-mon DNA modification found in most eukaryotic organisms
including plants, animals, and fungi (1, 2). The addition of a methyl group to cytosine …

DNA methylation, a DNA modification by adding methyl group to cytosine, has an important
role in the regulation of gene expression. DNA methylation is known to be associated with …

DNA methylation has an essential regulatory function in mammalian development, serving
to repress nontranscribed genes stably in differentiated adult somatic cells. Recent data …

The mammalian genome depends on patterns of methylated cytosines for normal function,
but the relationship between genomic methylation patterns and the underlying sequence is …

DNA methylation, histone deacetylation, and methylation of histone H3 at lysine 9 are the
three best-characterized covalent modifications associated with a repressed chromatin state …

DNA methylation was the first epigenetic modification to be detected in human cancers with
specific relation to aberrant gene expression. Herein, DNA methylation analysis explains …

Epigenetic regulation is the mechanism by which gene function is selectively activated or
inactivated in the cells. It provides higher-ordered and more specified genetic information …