Oligodendrocytes are preferentially sensitive to the toxic, carcinogenic, and teratogenic
effects of methylnitrosourea (MNU). The mechanisms responsible for this enhanced …

Glial cell types in the central nervous system are continuously exposed to reactive oxygen
species (ROS) due to their high oxygen metabolism and demonstrate differential …

Normal and malignant cells of the oligodendrocyte lineage show increased sensitivity to
alkylating agents compared to astrocytes. One of the most mutagenic DNA lesions formed …

Abstract Six chemicals, 2‐halopropionic acids, thiophene, methylhalides, methylmercury,
methylazoxymethanol (MAM) and trichlorfon (Fig. 1), that cause selective necrosis to the …

Neurons of the developing brain are especially vulnerable to environmental agents that
damage DNA (ie, genotoxicants), but the mechanism is poorly understood. The focus of the …

Within the central nervous system (CNS), there is a differential susceptibility among cell
types to certain pathological conditions believed to involve oxidative stress …

Aging is associated with impaired mitochondrial function caused by accumulation of oxygen
free radical-induced mitochondrial (Mt) DNA mutations. One prevailing theory is that age …

The major cellular antioxidant, glutathione, is mostly localized in the cytosol but a small
portion is found in mitochondria. We have recently shown that highly selective depletion of …

The status of both cytosolic and mitochondrial glutathione was studied in primary cultured
cerebrocortical cells from fetal mice using the selective membrane-solubilizing properties of …

Neurodegeneration can occur as a result of endogenous oxidative stress. Primary cerebellar
granule cells were used in this study to determine if mitochondrial DNA (mtDNA) repair …