Background The perfused elastase AAA model and subcutaneous Angiotensin II infusion
AAA model are widely used murine AAA models. We modified these two current models and …

Animal models of abdominal aortic aneurysms (AAA) enable preclinical studies on new
therapeutic approaches and help to understand pathophysiology of the disease. The aim of …

Remodeling in the abdominal aortic wall results in abdominal aortic aneurysm (AAA)
formation. Many patients with AAA are prescribed antihypertensive drugs. However, the …

The effects of angiotensin-converting-enzyme (ACE) inhibition on atherosclerosis-induced
changes in arterial function are unknown, as well as whether they are coupled to …

The effects of the selective AT2R (angiotensin AT2 receptor) agonist, Compound 21 (C21),
on abdominal aortic aneurysm formation were investigated in normotensive Wistar rats …

We investigated the effect of perindopril, a novel angiotensin-converting enzyme (ACE)
inhibitor, on neointima formation in vessel walls after balloon injury in rats (carotid artery) …

Background Abdominal aortic aneurysm (AAA) is a life-threatening disease that lacks
effective preventive therapies. This study aimed to evaluate the effect of pemafibrate, a …

Objective The angiotensin II type 1 receptor (AT1R) can be activated under conditions of
mechanical stretch in some cellular systems. Whether this activity influences signaling within …

Background Constructing an ideal model of abdominal aortic aneurysm (AAA) is of great
significance to elucidate its complex pathogenesis. Therefore, we introduce a new and …

Background. Infusion of the abdominal aorta with pancreatic elastase induces aneurysms in
a rat model (Anidjar/Dobrin). Because elastolysis liberates elastin degradation products …