Abdominal aortic aneurysm (AAA) represents a debilitating vascular disease characterized
by aortic dilatation and wall rupture if it remains untreated. We aimed to determine the effects …

An abdominal aortic aneurysm (AAA) is an enlargement of the greatest artery in the body
defined as an increase in diameter of 1.5-fold. AAAs are common in the elderly population …

OBJECTIVE: An ideal pharmaceutical treatment for abdominal aortic aneurysm (AAA) is to
prevent aneurysm formation and development (further dilatation of pre-existing aneurysm) …

Purpose Azelnidipine has recently been recognized in vascular remodeling. However, the
effects of azelnidipine on aneurysmal disease have not yet been studied. The aim of this …

Objective: There are no current effective abdominal aortic aneurysm (AAA) drug therapies.
An important limitation of most preclinical studies is that they test the effect of drugs on AAA …

Background—Thoracic aortic aneurysms (TAAs) are common, but experimental TAA models
are limited and the role of interleukin-1β (IL-1β) is undetermined. Methods and Results—IL …

We hypothesized that activation of the coagulation cascade is involved in arterial
remodeling in response to sequential injury. An active site–inhibited recombinant human …

Background Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. It is
controversial whether statin and calcium channel blockers (CCBs) has an inhibitory effect on …

A variety of animal models have been developed to better understand the pathophysiology
of AAA. The 3 most commonly used mouse AAA models are adventitial exposure to calcium …

Background Porcine pancreatic elastase (PPE) is successfully used to induce abdominal
aortic aneurysm (AAA) in mice. However, differences between mouse strains in susceptibility …