Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due
to medial disruption and results in luminal dilation and thrombus formation. The objective of …

To examine the possible role of the bradykinin-NO system in the action of ACE inhibitors, we
studied the effects of imidapril, an ACE inhibitor, on inflammatory vascular injury by using …

OBJECTIVES Our goal was to examine whether interleukin-1 beta (IL-1β) originates locally
and its possible relationship with matrix metalloproteinases (MMPs), apoptosis, elastin fibres …

Background Although data are inconsistent, angiotensin-converting enzyme inhibitors (ACE-
Is) have been associated with a reduced incidence of abdominal aortic aneurysm (AAA) …

Objective The goal of the present study was to test the safety and efficacy of chemical
stabilization of the arterial extracellular matrix as a novel nonoperative treatment of …

BACKGROUND: Monocyte activation, macrophage infiltration, vascular oxidative stress and
matrix proteolysis are inflammatory key steps contributing to abdominal aortic aneurysm …

We tested the hypothesis that pioglitazone (insulin sensitizer) reduces oxidative stress and
improves aortic wall distensibility in the pre-diabetic stage of Otsuka Long-Evans Tokushima …

Abdominal aortic aneurysm (AAA) is a prevalent and potentially life threatening disease.
Many animal models have been developed to simulate the natural history of the disease or …

BACKGROUND: Selective estrogen receptor modulators (SERMs), similar to estrogens,
possess vasoprotective effects by reducing release of reactive oxygen species. Little is …

Background: Abdominal aortic aneurysms (AAAs) are associated with chronic inflammation,
disruption of medial elastin, and increased local production of elastolytic matrix …