[PDF][PDF] Novel aspects of PPARα‐mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study

PGP Martin, H Guillou, F Lasserre, S Déjean… - …, 2007 - Wiley Online Library
Peroxisome proliferator‐activated receptor‐α (PPARα) is a major transcriptional regulator of
lipid metabolism. It is activated by diverse chemicals such as fatty acids (FAs) and regulates …

Peroxisome proliferator-activated receptor α mediates the effects of high-fat diet on hepatic gene expression

D Patsouris, JK Reddy, M Müller, S Kersten - Endocrinology, 2006 - academic.oup.com
Peroxisome proliferator-activated receptors (PPARs) are transcription factors involved in the
regulation of numerous metabolic processes. The PPARα isotype is abundant in liver and …

Comprehensive Analysis of PPARα‐Dependent Regulation of Hepatic Lipid Metabolism by Expression Profiling

M Rakhshandehroo, LM Sanderson… - PPAR …, 2007 - Wiley Online Library
PPARα is a ligand‐activated transcription factor involved in the regulation of nutrient
metabolism and inflammation. Although much is already known about the function of PPARα …

Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium

K Oshida, N Vasani, RS Thomas, D Applegate… - PloS one, 2015 - journals.plos.org
The nuclear receptor family member peroxisome proliferator-activated receptor α (PPARα) is
activated by therapeutic hypolipidemic drugs and environmentally-relevant chemicals to …

Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human

M Rakhshandehroo, G Hooiveld, M Müller, S Kersten - PloS one, 2009 - journals.plos.org
Background Studies in mice have shown that PPARα is an important regulator of hepatic
lipid metabolism and the acute phase response. However, little information is available on …

PPARs as metabolic regulators in the liver: lessons from liver-specific PPAR-null mice

Y Wang, T Nakajima, FJ Gonzalez… - International journal of …, 2020 - mdpi.com
Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis.
PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body …

[HTML][HTML] Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2

YK Lee, JE Park, M Lee, JP Hardwick - Liver research, 2018 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated
transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master …

Changes in liver PPARα mRNA expression in response to two levels of high-safflower-oil diets correlate with changes in adiposity and serum leptin in rats and mice

SC Hsu, C Huang - The Journal of nutritional biochemistry, 2007 - Elsevier
The ligand-dependent transcription factor peroxisome proliferator-activated receptor α
(PPARα) is known to be activated by common fatty acids and to regulate the expression of …

Transcriptional profiling reveals divergent roles of PPARα and PPARβ/δ in regulation of gene expression in mouse liver

LM Sanderson, MV Boekschoten… - Physiological …, 2010 - journals.physiology.org
Little is known about the role of the transcription factor peroxisome proliferator-activated
receptor (PPAR) β/δ in liver. Here we set out to better elucidate the function of PPARβ/δ in …

Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics

LM Sanderson, PJ de Groot, GJEJ Hooiveld, A Koppen… - PloS one, 2008 - journals.plos.org
Background The effect of dietary fats on human health and disease are likely mediated by
changes in gene expression. Several transcription factors have been shown to respond to …