Recent reports of strong selection of mitochondrial DNA (mtDNA) during transmission in
animal models of mtDNA disease, and of nuclear transfer in both animal models and …

Mitochondria, known as the energy factories in all cells, are key regulators of multiple vital
cellular processes and affect all aspects of mammalian reproduction, being essential for …

To investigate the applicability of preimplantation genetic diagnosis (PGD), we used
trophectoderm (TE) biopsy to determine the mutation load in a 35-year-old female with …

Background Severe, disease-causing germline mitochondrial (mt) DNA mutations are
maternally inherited or arise de novo. Strategies to prevent transmission are generally …

Prenatal diagnosis of mitochondrial DNA (mtDNA) mutations is technically possible, but has
only rarely been attempted. This is largely because of uncertainty about the effects of mtDNA …

STUDY QUESTION Does mitochondrial deficiency affect human embryonic preimplantation
development? SUMMARY ANSWER The presence of a pathogenic mitochondrial variant …

STUDY QUESTION Can quantification of mitochondrial DNA (mtDNA) in trophectoderm (TE)
biopsy samples provide information concerning the viability of a blastocyst, potentially …

BACKGROUND The use of nuclear transfer (NT) has been proposed as a novel
reproductive treatment to overcome the transmission of maternally-inherited mitochondrial …

Objective: To determine the patterns of mitochondrial inheritance in embryos, fetuses, and
infants after ooplasmic transplantation using the technique of mitochondrial DNA (mtDNA) …

Inherited diseases caused by mitochondrial gene (mtDNA) mutations affect at least 1 in
5000–10000 children and are associated with severe clinical symptoms. Novel reproductive …