Mitochondrialreplacementtherapy, an experimental approach that takes aim at maternally
inherited mitochondrial diseases, is on the verge of being implemented in the United …

The first licences permitting mito chondrial donation were issued in late 2017 by the Human
UK Fertilization and Embryo Authority (HFEA), the statutory authority charged with reg …

Objective Mitochondrial DNA (mtDNA) encodes the proteins of the electron transfer chain to
produce adenosine triphosphate through oxidative phosphorylation, and is essential to …

MRT opponents have raised several concerns, including possible harms from the disruption
of specific mitochondrial and nuclear genome interactions, based on possible evidence from …

Mitochondrial DNA (mtDNA) point mutations are known to accumulate in an age-dependent
fashion in somatic tissues. This study investigated whether a point mutation (T414G) in the …

Very recently, two papers have presented intriguing data suggesting that prevention of
transmission of human mitochondrial DNA (mtDNA) disease is possible.[Craven, L., Tuppen …

Recent reports suggest that mtDNA copy number may be used as a biomarker for embryo
viability. Further studies are necessary to determine whether mtDNA copy number …

Mitochondrial DNA (mtDNA) is almost entirely maternally inherited. Thousands of copies of
mtDNA are present in every nucleated cell and in most normal individuals these are virtually …

The mammalian mitochondrial genome (mtDNA) is a small double-stranded DNA molecule
that is exclusively transmitted down the maternal line. Pathogenic mtDNA mutations are …

Mitochondrial disorders are a group of diseases traditionally ascribed to defects of the
respiratory chain, which is the only metabolic pathway in the cell that is under the control of …