Although promoter-associated CpG islands have been established as targets of DNA
methylation changes in cancer, previous studies suggest that epigenetic dysregulation …

It is well established that DNA hypermethylation of tumor suppressor and tumor-related
genes can occur in cancer cells and that each cancer subtype has specific gene sets that …

The model describing that aberrant CpG island (CGI) methylation leads to repression of
tumour suppressor genes in cancers has been influential, but it remains unclear how such …

Epigenetic gene regulation is a key determinant of heritable gene expression patterns and is
critical for normal cellular function. Dysregulation of epigenetic transcriptional control is a …

Promoter CpG islands are typically unmethylated in normal cells, but in cancer a proportion
are subject to hypermethylation. Using methylome sequencing we identified CpG islands …

An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …

DNA methylation plays an important role in the regulation of gene expression, as it is the first
epigenetic modification to take place on a given DNA strand. Several factors may directly or …

Hypermethylation of CpG islands is a common epigenetic alteration associated with cancer.
Global patterns of hypermethylation are tumor-type specific and nonrandom. The biological …

Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is
one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of …

DNA methylation has a role in the regulation of gene expression during normal mammalian
development but can also mediate epigenetic silencing of CpG island genes in cancer and …