Imbalance of Th17/Treg cells in pathogenesis of patients with human leukocyte antigen B27 associated acute anterior uveitis

Z Zhuang, Y Wang, G Zhu, Y Gu, L Mao, M Hong, Y Li… - Scientific reports, 2017 - nature.com
Th17 and regulatory T cells, involved in the pathogenesis of several autoimmune diseases,
are new lineages of CD4+ T helper cells. However, the role of their imbalance in human …

The expression and significance of T helper cell subsets and regulatory T cells CD4 +CD25 + in peripheral blood of patients with human …

W Zou, Z Wu, X Xiang, S Sun, J Zhang - Graefe's Archive for Clinical and …, 2014 - Springer
Background Human leukocyte antigen B27 (HLA-B27)-associated uveitis is the most
common reason for non-infectious uveitis. This purpose of the research was to study the …

Imbalance between Th17 cells and regulatory T cells during monophasic experimental autoimmune uveitis

L Zhang, F Wan, J Song, K Tang, F Zheng, J Guo… - Inflammation, 2016 - Springer
The aim of this study is to explore the dynamic changes in IL-17-expressing T cells
(Th17)/Treg expression in monophasic experimental autoimmune uveitis (mEAU). mEAU …

[HTML][HTML] Coordinated gene expression of Th17-and Treg-associated molecules correlated with resolution of the monophasic experimental autoimmune uveitis

X Jia, M Hu, C Wang, C Wang, F Zhang, Q Han… - Molecular …, 2011 - ncbi.nlm.nih.gov
Purpose To investigate the role of T-cell-mediated immune response in a monophasic
experimental autoimmune uveitis (EAU). Methods A monophasic EAU was induced in Lewis …

Cytokine expression profile in aqueous humor and sera of patients with acute anterior uveitis

W Chen, B Zhao, R Jiang, R Zhang… - Current Molecular …, 2015 - ingentaconnect.com
Purpose: To evaluate cytokine expression profile in aqueous humor and sera in patients
with HLAB27 associated acute anterior uveitis (AAU) and idiopathic AAU. Methods: Twenty …

[PDF][PDF] Imbalance of Th17 to Th1 cells in Behçet's disease

J Kim, JA Park, EY Lee, YJ Lee, YW Song… - Clin Exp …, 2010 - clinexprheumatol.org
Objectives. Behçet's disease (BD) is a helper T cell-mediated autoimmune disease
characterised by recurrent orogenital ulcers, uveitis and skin lesions. The helper T cells are …

Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis

T Yoshimura, KH Sonoda, Y Miyazaki… - International …, 2008 - academic.oup.com
Abstract IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified
inflammatogenic cell population, which is critically involved in some inflammatory diseases …

Cytokines that modulate the differentiation of Th17 cells in autoimmune uveitis

K Guo, X Zhang - Journal of immunology research, 2021 - Wiley Online Library
Increasing evidence has suggested that T helper 17 (Th17) cells play a central role in the
pathogenesis of ocular immune disease. The association between pathogenic Th17 cells …

Th17 activation and Th17/Treg imbalance in prolonged anterior intraocular inflammation after ocular alkali burn

M Yuan, X Qian, Y Huang, X Ma, F Duan… - International Journal of …, 2022 - mdpi.com
Ocular alkali burn (OAB) is a sight-threatening disease with refractory ocular inflammation
causing various blinding complications. Th17 lymphocytes account for the pathogeneses of …

Clinical remission of sight-threatening non-infectious uveitis is characterized by an upregulation of peripheral T-regulatory cell polarized towards T-bet and TIGIT

RM Gilbert, X Zhang, RD Sampson… - Frontiers in …, 2018 - frontiersin.org
Background Non-infectious uveitis can cause chronic relapsing and remitting ocular
inflammation, which may require high dose systemic immunosuppression to prevent severe …