New Findings What is the topic of this review? The long‐held assumption that transcranial
Doppler middle cerebral artery velocity is a surrogate for cerebral blood flow has been …

Most hypobaric hypoxia studies have focused on oxygen delivery and therefore cerebral
blood inflow. Few have studied venous outflow. However, the volume of blood entering and …

Abstract Ainslie, Philip N., and Andrew W. Subudhi. Invited Review: Cerebral blood flow at
high altitude. High Alt Med Biol. 15: 133–140, 2014.—This brief review traces the last 50 …

Rapid ascent to high altitude commonly results in acute mountain sickness, and on occasion
potentially fatal high-altitude cerebral edema. The exact pathophysiological mechanisms …

It should be noted that Dr. JW Severinghaus was the expert author of this chapter (Cerebral
circulation at high altitude) in the First Edition of this textbook. Moreover, in updating this …

Cellular hypoxia is the common final pathway of brain injury that occurs not just after
asphyxia, but also when cerebral perfusion is impaired directly (eg, embolic stroke) or …

Traditionally, scientists and clinicians have explored peripheral physiological responses to
acute hypoxia to explain the pathophysiological processes that lead to acute mountain …

Abstract Wilson, Mark H., Alex Wright, and Christopher HE Imray. Intracranial pressure at
altitude. High Alt Med Biol. 15: 123–132, 2014.—Rapid ascent to high altitude can result in …

Background and Purpose—Acute mountain sickness (AMS) may be an early stage of high
altitude cerebral edema. If so, AMS could result from an alteration of dynamic autoregulation …

Abstract Imray, Christopher, Colin Chan, Alison Stubbings, Hannah Rhodes, Susannah
Patey, Mark H. Wilson, Damian M. Bailey, and Alex D. Wright for the Birmingham Medical …