The use of phenobarbital and other anti-seizure drugs in newborns

M El-Dib, JS Soul - Seminars in Fetal and Neonatal Medicine, 2017 - Elsevier
Neonatal seizures constitute the most frequent presenting neurologic sign encountered in
the neonatal intensive care unit. Despite limited efficacy and safety data, phenobarbital …

Treatment of seizures in the neonate: Guidelines and consensus‐based recommendations—Special report from the ILAE Task Force on Neonatal Seizures

RM Pressler, NS Abend, S Auvin, G Boylan, F Brigo… - …, 2023 - Wiley Online Library
Seizures are common in neonates, but there is substantial management variability. The
Neonatal Task Force of the International League Against Epilepsy (ILAE) developed …

A systematic review of the pharmacokinetics of antiepileptic drugs in neonates with refractory seizures

JK Tulloch, RR Carr… - The Journal of Pediatric …, 2012 - meridian.allenpress.com
BACKGROUND Neonatal seizures are associated with neurological sequelae and an
increased risk of epilepsy later in life. Phenobarbital and phenytoin remain the antiepileptic …

Pharmacotherapy for neonatal seizures: current knowledge and future perspectives

MD Donovan, BT Griffin, L Kharoshankaya, JF Cryan… - Drugs, 2016 - Springer
Seizures are the most common neurological emergencies in the neonatal period and are
associated with poor neurodevelopmental outcomes. Seizures affect up to five per 1000 …

[HTML][HTML] Changing antiepileptic drug use for seizures in US neonatal intensive care units from 2005 to 2014

KA Ahmad, SJ Desai, MM Bennett, SF Ahmad… - Journal of …, 2017 - nature.com
Objective: Neonatal seizures are a common problem in the neonatal intensive care unit and
are frequently treated with antiepileptic drugs. Limited data exist on current or changing …

Clinical management of seizures in newborns: diagnosis and treatment

LGM van Rooij, MPH van den Broek, CMA Rademaker… - Pediatric Drugs, 2013 - Springer
Neonatal seizures can be classified as tonic, clonic, myoclonic, and subtle. A clinical
diagnosis is not easy as seizures are usually subtle in neonates. In the majority of newborn …

Summary proceedings from the neurology group on neonatal seizures

RR Clancy - Pediatrics, 2006 - publications.aap.org
One of the highest risk periods for seizures during the human life span is the first month of
life. Most neonatal seizures are triggered by acute illness such as hypoxic-ischemic …

[HTML][HTML] Pharmacotherapy for seizures in neonates with hypoxic ischemic encephalopathy

E Yozawitz, A Stacey, RM Pressler - Pediatric Drugs, 2017 - Springer
Seizures are common in neonates with moderate and severe hypoxic ischemic
encephalopathy (HIE) and are associated with worse outcomes, independent of HIE …

Management of seizures in neonates with neonatal encephalopathy treated with hypothermia

O DeLaGarza-Pineda, JA Mailo, G Boylan… - Seminars in Fetal and …, 2021 - Elsevier
Neonatal encephalopathy (NE) is the most common etiology of acute neonatal seizures–
about half of neonates treated with therapeutic hypothermia for NE have EEG-confirmed …

Phenobarbitone versus phenytoin for treatment of neonatal seizures: An open-label randomized controlled trial

G Pathak, A Upadhyay, U Pathak, D Chawla, SP Goel - Indian pediatrics, 2013 - Springer
Objective To compare the efficacy of phenobarbitone and phenytoin for treatment of
neonatal seizures in term and nearterm neonates. Design Open labeled randomized …