We have investigated the DNA methylation patterns in genomically imprinted genes of the
mouse. Both Igf2 and H19 are associated with clear‐cut regions of allele‐specific paternal …

The Insulin-like growth factor 2 (Igf2) and H19 genes are reciprocally imprinted and closely
linked. Igf2 encodes a fetal growth-factor and is predominantly expressed from the paternal …

ABSTRACT A number of transgenes in the mouse show variation in methylation and
expression phenotypes dependent on parental transmission. It appears that there exist at …

The mouse insulin-like growth factor II (Igf2) gene, which is located on distal chromosome 7
(Chr7), has been shown previously to undergo tissue-specific parental imprinting. This …

The human 1GF2R gene has been reported to be either blallelically or very rarely
monoallelically expressed, in contrast to the maternally expressed mouse counterpart. We …

Embryonic stem (ES) cells homozygous for a disruption of the DNA (cytosine-5)-
methyltransferase gene (Dnmt) proliferate normally with their DNA highly demethylated but …

In some lines of transgenic mice, the methylation of Mspl sites within or adjacent to the
transgene locus is affected by the sex of the parent from which the transgene is inherited …

It has recently been shown that functional differences between parental genomes in the
developing mouse can be attributed to germ-line specific modifications (imprinting) of certain …

Recent investigations have shown that the maintenance of genomic imprinting of the murine
insulin-like growth factor 2 (Igf2) gene involves at least two factors: the DNA (cytosine-5-) …

The DNA MTase gene was disrupted by homologous recombination as described previously
(Li et al. 1992). The targeting vector contained a 900-bp deletion extending from the NaeI …