The ontogeny of allele‐specific methylation associated with imprinted genes in the mouse.
M Brandeis, T Kafri, M Ariel, JR Chaillet… - The EMBO …, 1993 - embopress.org
We have investigated the DNA methylation patterns in genomically imprinted genes of the
mouse. Both Igf2 and H19 are associated with clear‐cut regions of allele‐specific paternal …
mouse. Both Igf2 and H19 are associated with clear‐cut regions of allele‐specific paternal …
Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes
The Insulin-like growth factor 2 (Igf2) and H19 genes are reciprocally imprinted and closely
linked. Igf2 encodes a fetal growth-factor and is predominantly expressed from the paternal …
linked. Igf2 encodes a fetal growth-factor and is predominantly expressed from the paternal …
Imprinting by DNA methylation: from transgenes to endogenous gene sequences
W Reik, SK Howlett, MA Surani - Development, 1990 - journals.biologists.com
ABSTRACT A number of transgenes in the mouse show variation in methylation and
expression phenotypes dependent on parental transmission. It appears that there exist at …
expression phenotypes dependent on parental transmission. It appears that there exist at …
Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.
The mouse insulin-like growth factor II (Igf2) gene, which is located on distal chromosome 7
(Chr7), has been shown previously to undergo tissue-specific parental imprinting. This …
(Chr7), has been shown previously to undergo tissue-specific parental imprinting. This …
Conservation of a maternal-specific methylation signal at the human IGF2R locus
OW Smrzka, I Faé, R Stöger, R Kurzbauer… - Human molecular …, 1995 - academic.oup.com
The human 1GF2R gene has been reported to be either blallelically or very rarely
monoallelically expressed, in contrast to the maternally expressed mouse counterpart. We …
monoallelically expressed, in contrast to the maternally expressed mouse counterpart. We …
Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes.
KL Tucker, C Beard, J Dausmann… - Genes & …, 1996 - genesdev.cshlp.org
Embryonic stem (ES) cells homozygous for a disruption of the DNA (cytosine-5)-
methyltransferase gene (Dnmt) proliferate normally with their DNA highly demethylated but …
methyltransferase gene (Dnmt) proliferate normally with their DNA highly demethylated but …
Epigenetic and genetic factors affect transgene methylation imprinting
C Sapienza, J Paquette, TH Tran, A Peterson - Development, 1989 - journals.biologists.com
In some lines of transgenic mice, the methylation of Mspl sites within or adjacent to the
transgene locus is affected by the sex of the parent from which the transgene is inherited …
transgene locus is affected by the sex of the parent from which the transgene is inherited …
Transgenes as molecular probes for genomic imprinting.
It has recently been shown that functional differences between parental genomes in the
developing mouse can be attributed to germ-line specific modifications (imprinting) of certain …
developing mouse can be attributed to germ-line specific modifications (imprinting) of certain …
Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans
T Forne, J Oswald, W Dean, JR Saam… - Proceedings of the …, 1997 - National Acad Sciences
Recent investigations have shown that the maintenance of genomic imprinting of the murine
insulin-like growth factor 2 (Igf2) gene involves at least two factors: the DNA (cytosine-5-) …
insulin-like growth factor 2 (Igf2) gene involves at least two factors: the DNA (cytosine-5-) …
DNA methylation, genomic imprinting, and mammalian development
E Li, C Beard, AC Forster, TH Bestor… - Cold Spring Harbor …, 1993 - symposium.cshlp.org
The DNA MTase gene was disrupted by homologous recombination as described previously
(Li et al. 1992). The targeting vector contained a 900-bp deletion extending from the NaeI …
(Li et al. 1992). The targeting vector contained a 900-bp deletion extending from the NaeI …