Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain
K Fellinger, U Rothbauer, M Felle… - Journal of cellular …, 2009 - Wiley Online Library
DNA methylation is a major epigenetic modification and plays a crucial role in the regulation
of gene expression. Within the family of DNA methyltransferases (Dnmts), Dnmt3a and 3b …
of gene expression. Within the family of DNA methyltransferases (Dnmts), Dnmt3a and 3b …
Interactions within the mammalian DNA methyltransferase family
JB Margot, AE Ehrenhofer-Murray, H Leonhardt - BMC molecular biology, 2003 - Springer
Background In mammals, epigenetic information is established and maintained via the
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
Cell and molecular biology of DNA methyltransferase 1
KN Mohan, JR Chaillet - International review of cell and molecular biology, 2013 - Elsevier
The DNA cytosine methyltransferase 1 (DNMT1) is a ubiquitous nuclear enzyme that
catalyzes the well-established reaction of placing methyl groups on the unmethylated …
catalyzes the well-established reaction of placing methyl groups on the unmethylated …
Structural basis of DNMT1 and DNMT3A-mediated DNA methylation
DNA methylation, one of the major epigenetic mechanisms, plays critical roles in regulating
gene expression, genomic stability and cell lineage commitment. The establishment and …
gene expression, genomic stability and cell lineage commitment. The establishment and …
Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions
S Takebayashi, T Tamura, C Matsuoka… - Molecular and cellular …, 2007 - Taylor & Francis
DNA methyltransferase 1 (DNMT1) plays an important role in the inheritance of genomic
DNA methylation, which is coupled to the DNA replication process. Early embryonic lethality …
DNA methylation, which is coupled to the DNA replication process. Early embryonic lethality …
Mammalian DNA methyltransferases show different subnuclear distributions
JB Margot, MC Cardoso… - Journal of cellular …, 2001 - Wiley Online Library
In mammalian cells, DNA methylation patterns are precisely maintained after DNA
replication with defined changes occurring during development. The major DNA …
replication with defined changes occurring during development. The major DNA …
The amino-terminus of mouse DNA methyltransferase 1 forms an independent domain and binds to DNA with the sequence involving PCNA binding motif
DNA methylation patterns in genome are maintained during replication by a DNA
methyltransferase Dnmt1. Mouse Dnmt1 is a 180 kDa protein comprising the N-terminal …
methyltransferase Dnmt1. Mouse Dnmt1 is a 180 kDa protein comprising the N-terminal …
Regulation of DNA methyltransferase 1
F Spada, U Rothbauer, K Zolghadr… - Advances in enzyme …, 2006 - Elsevier
Although essentially all cells of a mammalian organism contain the same genetic
information they may differ dramatically in form and function. This cellular differentiation is …
information they may differ dramatically in form and function. This cellular differentiation is …
Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro
AK Robertson, TM Geiman, UT Sankpal… - Biochemical and …, 2004 - Elsevier
DNA methylation is an epigenetic modification of the genome critical for numerous
processes, including transcriptional repression and maintenance of chromatin structure …
processes, including transcriptional repression and maintenance of chromatin structure …
The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an …
M Fatemi, A Hermann, S Pradhan, A Jeltsch - Journal of molecular biology, 2001 - Elsevier
The mammalian DNA methyltransferase Dnmt1 is responsible for the maintenance of the
pattern of DNA methylation in vivo. It is a large multidomain enzyme comprising 1620 amino …
pattern of DNA methylation in vivo. It is a large multidomain enzyme comprising 1620 amino …