DNA methylation is part of the epigenetic gene regulation complex, which is relevant for the
pathogenesis of cancer. We performed a genome-wide search for methylated CpG islands …

BACKGROUND Aberrant DNA methylation of the CpG islands for cancer‐related genes is
among the earliest and most frequent alterations in cancer and may be useful for diagnosing …

Abstract Changes in DNA methylation patterns are an important characteristic of human
cancer including lung cancer. In particular, hypermethylation of CpG islands is a signature of …

Recent analyses of global and gene-specific methylation patterns in cancer cells have
suggested that cancers from different organs demonstrate distinct patterns of CpG island …

Changes in DNA methylation patterns are an important characteristic of human cancer.
Tumors have reduced levels of genomic DNA methylation and contain hypermethylated …

Background Promoter hypermethylation coupled with loss of heterozygosity at the same
locus results in loss of gene function in many tumor cells. The “rules” governing which genes …

Epigenetic changes, including DNA methylation, are a common finding in cancer. In lung
cancers methylation of cytosine residues may affect tumor initiation and progression in …

In this study, microarray analysis was used to identify tumour-related genes that were down
regulated in lung carcinoma. The promoter sequences of the identified genes were analysed …

Purpose: Non–small cell lung cancer (NSCLC) is the leading cause of cancer mortality in the
world. Novel diagnostic biomarkers may augment both existing NSCLC screening methods …

Background Despite of intense research in early cancer detection, there is a lack of
biomarkers for the reliable detection of malignant tumors, including non-small cell lung …