Maternal high-fat diet acts as a stressor increasing maternal glucocorticoids' signaling to the fetus and disrupting maternal behavior and brain activation in C57BL/6J …

V Bellisario, P Panetta, G Balsevich, V Baumann… - …, 2015 - Elsevier
Maternal diet during pregnancy can impact maternal behavior as well as the intrauterine
environment, playing a critical role in programming offspring's physiology. In a preliminary …

Maternal high fat diet programs hypothalamic-pituitary-adrenal function in adult rat offspring

XT Niu, XY Wu, AN Ying, B Shao, XF Li… - …, 2019 - Elsevier
Maternal environmental factors such as diet have profound effects on offspring development
and later health. The hypothalamic-pituitary-adrenal (HPA) axis is an important stress …

Perinatal high fat diet induces early activation of endocrine stress responsivity and anxiety-like behavior in neonates

S Abuaish, RL Spinieli, PO McGowan - Psychoneuroendocrinology, 2018 - Elsevier
The maternal environment has a profound effect on the development of offspring, including
responses to stress mediated by the hypothalamic-pituitary-adrenal (HPA) axis. In rodents …

Maternal high-fat diet programs offspring emotional behavior in adulthood

G Winther, B Elfving, HK Müller, S Lund, G Wegener - Neuroscience, 2018 - Elsevier
Prenatal exposure to high-fat diet (HFD) might predispose offspring to develop metabolic
and mental disorders later in life. Insight into the molecular and behavioral consequences of …

[HTML][HTML] Maternal high-fat diet during pre-conception and gestation predisposes adult female offspring to metabolic dysfunction in mice

B Akhaphong, B Gregg, D Kumusoglu… - Frontiers in …, 2022 - frontiersin.org
The risk of obesity in adulthood is subject to programming in the womb. Maternal obesity
contributes to programming of obesity and metabolic disease risk in the adult offspring. With …

Effects of high fat diet-induced obesity and pregnancy on prepartum and postpartum maternal mouse behavior

S Moazzam, JS Jarmasz, Y Jin, TJ Siddiqui… - …, 2021 - Elsevier
Obesity before and during pregnancy negatively affects the mental and physical health of
the mother. A diet high in fat also increases the risk for anxiety, depression and cognitive …

Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in …

S Wijenayake, MF Rahman, CMW Lum… - Journal of …, 2020 - Springer
Background Maternal obesity as a result of high levels of saturated fat (HFD) consumption
leads to significant negative health outcomes in both mother and exposed offspring …

Exposure to a high-fat diet during early development programs behavior and impairs the central serotonergic system in juvenile non-human primates

JR Thompson, JC Valleau, AN Barling… - Frontiers in …, 2017 - frontiersin.org
Perinatal exposure to maternal obesity and high-fat diet (HFD) consumption not only poses
metabolic risks to offspring but also impacts brain development and mental health. Using a …

Overnutrition during pregnancy and lactation induces gender-dependent dysmetabolism in the offspring accompanied by heightened stress and anxiety

GM Melo, AM Capucho, JF Sacramento… - Nutrients, 2023 - mdpi.com
Maternal obesity and gestational diabetes predispose the next generation to metabolic
disturbances. Moreover, the lactation phase also stands as a critical phase for metabolic …

Maternal high fat diet in lactation impacts hypothalamic neurogenesis and neurotrophic development, leading to later life susceptibility to obesity in male but not …

Y Xu, D Yang, L Wang, E Król, M Mazidi, L Li… - Advanced …, 2023 - Wiley Online Library
Early life nutrition can reprogram development and exert long‐term consequences on body
weight regulation. In mice, maternal high‐fat diet (HFD) during lactation predisposed male …