Extracellular matrix alterations have been suggested to be part of the early events occurring
in Autosomal Dominant Polycystic Kidney Disease (ADPKD), a disease characterized by …

In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …

Renal cyst formation is the hallmark of autosomal dominant polycystic kidney disease
(ADPKD). ADPKD cyst-lining cells have an increased proliferation rate and are surrounded …

Polycystic kidney disease (PKD), in which epithelial cysts arise from or instead of normal
renal tubules, is one of the most common genetic diseases. It has both autosomal dominant …

Basement membrane abnormalities have often been observed in kidney cysts of polycystic
kidney disease (PKD) patients and animal models. There is an abnormal deposition of …

Extracellular matrix abnormalities have been found in both human and animal models of
polycystic kidney disease (PKD). A new mouse PKD model has been produced through …

Abstract Background/Aims: Dysregulation of integrins is a feature of tissue remodeling in
autosomal-dominant polycystic kidney disease (ADPKD). The alpha 8 beta 1 integrin (α8β1) …

Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …

The main laminin-binding integrins α3β1, α6β1 and α6β4 are co-expressed in the
developing kidney collecting duct system. We previously showed that deleting the integrin …

Interaction of polycystin-1 (PC1) and Gα12 is important for development of kidney cysts in
autosomal dominant polycystic kidney disease (ADPKD). The integrity of cell polarity and …