The acquisition of expression of hTERT, the catalytic subunit of the telomerase enzyme,
seems to be an essential step in the development of a majority of human tumors. However …

The promoter of the hTERT gene encoding the catalytic subunit of telomerase was recently
cloned and has a dense CG-rich CpG island, suggesting a role for methylation in regulation …

DNA methylation is an epigenetic process involved in embryonic development,
differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in …

Activation of telomerase is a crucial step during cellular immortalization and malignant
transformation of human cells and requires the induction of the catalytic component, human …

Telomerase is the ribonucleoproteic complex involved in maintaining telomere size. It is
expressed in germ and stem cells but not in normal somatic cells. In most tumors …

The promoter region of the gene encoding the human telomerase reverse transcriptase
(hTERT) is located in a CpG island and was shown to be regulated, at least in part, by DNA …

The immortal phenotype of most human cancers is attributable to telomerase expression.
However, a number of immortal cell lines and tumors achieve telomere maintenance in the …

The expression of telomerase reverse transcriptase (hTERT), the catalytic component of the
telomerase complex, is required for activation of telomerase during immortalization and …

Telomerase is required for the complete replication of chromosomal ends. In tumors, the
human telomerase reverse transcriptase subunit (hTERT) is up-regulated, thereby removing …

Once immortalized, human cells are susceptible to transformation by introduction of an
oncogene such as ras. Several lines of evidence now suggest that the maintenance of …