In the current study, the authors found a correlation between vascular endothelial growth
factor (VEGF) overexpression and both biallelic and monoallelic von Hippel‐Lindau (VHL) …

PURPOSE: The von Hippel-Lindau (VHL) tumor suppressor gene is frequently inactivated in
the common type of sporadic clear cell renal cell carcinoma (RCC) as well as RCCs …

Mutation or loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is
regularly found in sporadic renal cell carcinomas (RCC), well vascularized malignant tumors …

Tumors associated with the VHL (von Hippel-Lindau) disease, such as hemangioblastomas
and renal carcinomas and their sporadic counterparts, are cystic and well vascularized …

Mutations or loss of both alleles of the von Hippel-Lindau (VHL) tumor suppressor gene has
been documented in sporadic renal cell carcinomas and neoplasms that arise in individuals …

Background: The von Hippel–Lindau gene (VHL) alteration, a common event in sporadic
clear-cell renal-cell carcinoma (CCRCC), leads to highly vascularised tumours. Vascular …

The von Hippel-Lindau tumor suppressor gene (VHL) has a critical role in the pathogenesis
of clear-cell renal cell carcinoma (RCC), as VHL mutations have been found in both von …

Mutations of the VHL tumor suppressor gene occur in patients with VHL disease and in the
majority of sporadic clear cell renal carcinomas (VHL−/− RCC). Loss of VHL protein function …

Angiogenesis is essential for tumor growth and metastasis. It is regulated by numerous
angiogenic factors, one of the most important being vascular endothelial growth factor …

Abstract von Hippel-Lindau (VHL) disease results from germline and somatic mutations in
the VHL tumor suppressor gene and is characterized by highly vascularized tumors. VHL …