Integrin-associated focal adhesion complex formation and turnover plays an essential role in
directing interactions between epithelial cells and the extracellular matrix during …

This short review summarizes some information concerning what is known about matrix
adhesion molecules, focal adhesion proteins, and cell-cell adhesion molecules in normal …

Polycystin 1, the product of the PKD1 gene, is mutated in autosomal dominant polycystic
kidney disease, a disease characterized by renal cyst formation and progressive renal …

The PKD1 protein, polycystin-1, is a large transmembrane protein of uncertain function and
topology. To study the putative functions of polycystin-1, conditionally immortalized kidney …

Polycystic kidney disease is the most common heritable disease in humans. In addition to
epithelial cysts in the kidney, liver and pancreas, patients with autosomal dominant …

Autosomal dominant polycystic kidney disease (ADPKD) is typified by the accumulation of
fluid-filled cysts and abnormalities in renal epithelial cell function. The disease is principally …

Abstract Mutations in polycystin-1 (PC-1) are responsible for autosomal dominant polycystic
kidney disease (ADPKD), characterized by formation of fluid-filled tubular cysts. The PC-1 is …

Polycystin-1, the product of the major gene mutated in autosomal dominant polycystic kidney
disease (ADPKD), has been shown to associate with multiple epithelial cell junctions. Our …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited
human renal disease and is caused by mutations in two genes, PKD1 (85%) and PKD2 …

Mutations of the Pkhd1 gene cause autosomal recessive polycystic kidney disease
(ARPKD). Pkhd1 encodes fibrocystin/polyductin (FPC), a ciliary type I membrane protein of …