Purpose The current evaluation methods for tumor infiltrating lymphocytes (TILs), particularly
CD8+ TILs, mainly rely on semiquantitative immunohistochemistry with high variability. We …

The presence of immune cells in the tumor microenvironment has been associated with
response to immunotherapies across several cancer types, including melanoma. Despite its …

Cutaneous melanoma (CM) is a life-threatening form of skin cancer. Prognostic biomarkers
can reliably stratify patients at initial melanoma diagnosis according to risk, and may inform …

Background Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, can be used for
predicting immunotherapy responsiveness and survival outcome. However, the evaluation …

Understanding of the tumor microenvironment (TME) structure is likely to have a profound
and immediate impact on therapeutic interventions as well as the development of signatures …

Abstract The prognosis for Cutaneous Melanoma (CM), a skin malignant tumor that is
extremely aggressive, is not good. A recently identified type of controlled cell death that is …

Background DNA methylation profiles have emerged as potential predictors of therapeutic
response in various solid tumors. Objective This study aimed to analyze the DNA …

Tumor immunogenicity is driven by various genomic and transcriptomic factors but the
association with the overall status of methylation aberrancy is not well established. We …

Background DNA methylation at CpG dinucleotides is modified in tumorigenesis with
potential impact on transcriptional activity. Methods We used the Illumina 450 K platform to …

Background Therapies based on targeting immune checkpoints have revolutionized the
treatment of metastatic melanoma in recent years. Still, biomarkers predicting long-term …