Thyroid hormone is essential for normal metabolism and development, and overt
abnormalities in thyroid function lead to common endocrine disorders affecting …

Context Genetic factors are major determinants of thyroid function. Over the last two
decades, multiple genetic variants have been associated with variations in normal range …

For a long time it has been known that both hypo-and hyperthyroidism are associated with
an increased risk of morbidity and mortality. In recent years, it has also become clear that …

Normal thyroid function is essential for health, but its genetic architecture remains poorly
understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4) …

Objective Minor variation in serum thyroid hormone (TH) levels can have important effects
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …

Abstract Effects of thyroid hormones in individual tissues are determined by many factors
beyond their serum levels, including local deiodination and expression and activity of thyroid …

Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general
population. Here we present the current largest genome-wide association study of …

Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To
better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis …

Thyroid diseases, including autoimmune thyroid diseases and thyroid cancer, are known to
have high heritability. Family and twin studies have indicated that genetics plays a major …

Thyroid dysfunction is an important public health problem, which affects 10% of the general
population and increases the risk of cardiovascular morbidity and mortality. Many aspects of …