A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function
E Porcu, M Medici, G Pistis, CB Volpato… - PLoS …, 2013 - journals.plos.org
Thyroid hormone is essential for normal metabolism and development, and overt
abnormalities in thyroid function lead to common endocrine disorders affecting …
abnormalities in thyroid function lead to common endocrine disorders affecting …
The genetic basis of thyroid function: novel findings and new approaches
A Kuś, L Chaker, A Teumer, RP Peeters… - The Journal of Clinical …, 2020 - academic.oup.com
Context Genetic factors are major determinants of thyroid function. Over the last two
decades, multiple genetic variants have been associated with variations in normal range …
decades, multiple genetic variants have been associated with variations in normal range …
Genetic determination of the hypothalamic-pituitary-thyroid axis: where do we stand?
M Medici, WE Visser, TJ Visser, RP Peeters - Endocrine reviews, 2015 - academic.oup.com
For a long time it has been known that both hypo-and hyperthyroidism are associated with
an increased risk of morbidity and mortality. In recent years, it has also become clear that …
an increased risk of morbidity and mortality. In recent years, it has also become clear that …
Whole-genome sequence-based analysis of thyroid function
Normal thyroid function is essential for health, but its genetic architecture remains poorly
understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4) …
understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4) …
A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels
M Medici, WM Van Der Deure… - European journal of …, 2011 - academic.oup.com
Objective Minor variation in serum thyroid hormone (TH) levels can have important effects
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …
Novel insights into thyroid hormones from the study of common genetic variation
CM Dayan, V Panicker - Nature Reviews Endocrinology, 2009 - nature.com
Abstract Effects of thyroid hormones in individual tissues are determined by many factors
beyond their serum levels, including local deiodination and expression and activity of thyroid …
beyond their serum levels, including local deiodination and expression and activity of thyroid …
Novel associations for hypothyroidism include known autoimmune risk loci
Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general
population. Here we present the current largest genome-wide association study of …
population. Here we present the current largest genome-wide association study of …
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To
better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis …
better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis …
Genome-wide association studies of autoimmune thyroid diseases, thyroid function, and thyroid cancer
Thyroid diseases, including autoimmune thyroid diseases and thyroid cancer, are known to
have high heritability. Family and twin studies have indicated that genetics plays a major …
have high heritability. Family and twin studies have indicated that genetics plays a major …
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
A Teumer, L Chaker, S Groeneweg, Y Li… - Nature …, 2018 - nature.com
Thyroid dysfunction is an important public health problem, which affects 10% of the general
population and increases the risk of cardiovascular morbidity and mortality. Many aspects of …
population and increases the risk of cardiovascular morbidity and mortality. Many aspects of …