DNA methylation is an epigenetic process involved in development, aging, and cancer.
Although the advent of new molecular techniques has enhanced our knowledge of how …

DNA methylation patterns are disrupted in various malignancies, suggesting a role in the
development of cancer, but genetic aberrations directly linking the DNA methylation …

The gene that encodes de novo DNA methyltransferase 3A (DNMT3A) is frequently mutated
in acute myeloid leukemia genomes. Point mutations at position R882 have been shown to …

Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur
frequently in acute myeloid leukemia and other hematological malignancies, with the …

DNA methyltransferases (DNMTs) are the key enzymes for genome methylation, which plays
an important role in epigenetically regulated gene expression and repression. Mouse …

In the last decade, large-scale genomic studies in patients with hematologic malignancies
identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de …

DNA methyltransferases (DNMTs) are an evolutionarily conserved family of DNA
methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The …

DNMT3A, a DNA methyltransferase that functions for de novo methylation, is important in
development and many cellular processes related to tumorigenesis. Somatic mutations of …

Acute myeloid leukaemia (AML) is a haematological malignancy characterized by clonal
stem cell proliferation and aberrant block in differentiation. Dysfunction of epigenetic …

Eukaryotic DNA methylation prevents genomic instability by regulating the expression of
oncogenes and tumor-suppressor genes. The negative effects of dysregulated DNA …