Aberrant hypermethylation of tumor suppressor genes plays an important role in the
development of many tumors. Recently identified new DNA methyltransferase (DNMT) …

DNA methylation is essential for development and in diverse biological processes. The DNA
methyltransferase Dnmt1 maintains parental cell methylation patterns on daughter DNA …

DNA cytosine methylation is an epigenetic modification involved in the transcriptional
repression of genes controlling a variety of physiological processes, including …

It has been recently shown that DNA methyl transferase overexpression is correlated with
unfavourable prognosis in human malignancies while methylation deregulation remains a …

Alterations in DNA methylation have been implicated in the pathogenesis of myelodysplastic
syndromes (MDS), although the underlying mechanism remains largely unknown …

Abnormal epigenetic regulation has been implicated in oncogenesis. We report here the
identification of somatic mutations by exome sequencing in acute monocytic leukemia, the …

Overgrowth disorders are a heterogeneous group of conditions characterized by increased
growth parameters and other variable clinical features such as intellectual disability and …

New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic
mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias …

DNMT3A is one of two human de novo DNA methyltransferases essential for regulating
gene expression through cellular development and differentiation. Here we describe the …

Gains and losses in DNA methylation are prominent features of mammalian cell types. To
gain insight into the mechanisms that promote shifts in DNA methylation and contribute to …