Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in
adults. The presence of epigenetic lesions, like hypermethylation of known tumor …

Few studies had investigated genome-wide methylation in glioblastoma multiforme (GBM).
Our goals were to study differential methylation across the genome in gene promoters using …

Background Changes in promoter DNA methylation pattern of genes involved in key
biological pathways have been reported in glioblastoma. Genome-wide assessments of …

Glioblastoma multiforme (GBM) is the most frequent brain tumor in adults. This lethal cancer
is a challenge in neuro-oncology since patients almost invariably succumb to the disease …

Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …

Different gene expression and methylation profiles are identified in glioblastoma (GBM). To
screen the differentially expressed genes affected by DNA methylation modification and …

Epigenetic changes in DNA methylation contribute to the development of many diseases,
including cancer. In glioblastoma multiforme, the most prevalent primary brain cancer and …

Background A feature of glioblastoma (GBM) is cellular and molecular heterogeneity, both
within and between tumors. This variability causes a risk for sampling bias and potential …

The downregulation of specific genes through DNA hypermethylation is a major hallmark of
cancer, although the extent and genomic distribution of hypermethylation occurring within …

DNA methylation is an important regulator of gene expression, and plays a significant role in
carcinogenesis in the brain. Here, we explored specific prognosis-subtypes based on DNA …