Current evidence and future directions of tranexamic acid use, efficacy, and dosing for major surgical procedures
J Taam, QJ Yang, KS Pang, P Karanicolas… - Journal of cardiothoracic …, 2020 - Elsevier
Tranexamic acid reduces blood loss and transfusion requirements with no significant
thrombotic adverse effects. Postoperative seizures have been seen in cardiac surgical …
thrombotic adverse effects. Postoperative seizures have been seen in cardiac surgical …
What dose of tranexamic acid is most effective and safe for adult patients undergoing cardiac surgery?
S Hodgson, JT Larvin, C Dearman - … cardiovascular and thoracic …, 2015 - academic.oup.com
A best evidence topic in cardiac surgery was written according to a structured protocol. The
question addressed was: what dose of tranexamic acid is most effective and safe for adult …
question addressed was: what dose of tranexamic acid is most effective and safe for adult …
Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass
We conducted a study to assess pharmacokinetics of high‐dose tranexamic acid for 24 h
after administration of the drug in patients undergoing cardiac surgery with cardiopulmonary …
after administration of the drug in patients undergoing cardiac surgery with cardiopulmonary …
A preliminary study of a new tranexamic acid dosing schedule for cardiac surgery
GA Nuttall, MC Gutierrez, JD Dewey… - Journal of cardiothoracic …, 2008 - Elsevier
Objective (s): The authors have developed an alternative dosing schedule for tranexamic
acid that incorporates the effects of renal function on tranexamic acid concentrations. The …
acid that incorporates the effects of renal function on tranexamic acid concentrations. The …
Exposure–response relationship of tranexamic acid in cardiac surgery: a model-based meta-analysis
PJ Zufferey, J Lanoiselee, B Graouch, B Vieille… - …, 2021 - pubs.asahq.org
Background It is unclear whether high-dose regimens of tranexamic acid in cardiac surgery
(total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose …
(total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose …
Tranexamic acid administration after cardiac surgery: a prospective, randomized, double-blind, placebo-controlled study
V Casati, F Bellotti, C Gerli, A Franco… - The Journal of the …, 2001 - pubs.asahq.org
Background Many different doses and administration schemes have been proposed for the
use of the antifibrinolytic drug tranexamic acid during cardiac surgery. This study evaluated …
use of the antifibrinolytic drug tranexamic acid during cardiac surgery. This study evaluated …
Risk factors associated with postoperative seizures in patients undergoing cardiac surgery who received tranexamic acid: a case-control study
FR Montes, DF Pardo, M Carreño… - Annals of cardiac …, 2012 - journals.lww.com
Antifibrinolytic agents are used during cardiac surgery to minimize bleeding and reduce
exposure to blood products. Several reports suggest that tranexamic acid (TA) can induce …
exposure to blood products. Several reports suggest that tranexamic acid (TA) can induce …
Different dose regimes and administration methods of tranexamic acid in cardiac surgery: a meta-analysis of randomized trials
J Guo, X Gao, Y Ma, H Lv, W Hu, S Zhang, H Ji… - BMC …, 2019 - Springer
Background The efficacy of tranexamic acid (TXA) to reduce perioperative blood loss and
allogeneic blood transfusion in cardiac surgeries has been proved in previous studies, but …
allogeneic blood transfusion in cardiac surgeries has been proved in previous studies, but …
Tranexamic acid dosing for cardiac surgical patients with chronic renal dysfunction: a new dosing regimen
A Jerath, QJ Yang, KS Pang, N Looby… - Anesthesia & …, 2018 - journals.lww.com
BACKGROUND: Tranexamic acid (TXA) is a common antifibrinolytic agent used to minimize
bleeding in cardiac surgery. Up to 50% cardiac surgical patients have chronic renal …
bleeding in cardiac surgery. Up to 50% cardiac surgical patients have chronic renal …
Comparison of two doses of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass
S Sigaut, B Tremey, A Ouattara, R Couturier… - …, 2014 - pubs.asahq.org
Background: The optimal dose of tranexamic acid (TA) is still an issue. The authors
compared two doses of TA during cardiac surgery in a multicenter, double-blinded …
compared two doses of TA during cardiac surgery in a multicenter, double-blinded …