The article deals with the issue of topical use of tranexamic acid in cardiac surgery. Four
randomized, double-blind trials comparing tranexamic acid vs. placebo were identified in the …

Background Tranexamic acid reduces blood loss and transfusion requirements in cardiac
surgery but may increase the risk of coronary graft thrombosis. We previously reported the …

Background Bleeding and transfusions affect mortality in aortic surgery. Although tranexamic
acid significantly reduced bleeding in multiple settings, its role in major vascular surgery was …

We evaluated the effects of tranexamic acid (TA) administered before and after
cardiopulmonary bypass (CPB) in a prospective, randomized, placebo-controlled, double …

Standard dose is 1g intravenously, over a minimum of 10 minutes. The main mechanism of
action is anti-fibrinolytic activity. It also possesses anti-inflammatory effects and may help …

Background Tranexamic acid (TXA) reduces blood transfusion in surgery but the extent of
the reduction in blood loss and how it relates to the dose of TXA is unclear. Methods A …

OBJECTIVE: This study was designed to evaluate the hemostatic effect of tranexamic acid in
off-pump coronary artery bypass surgery. DESIGN: A prospective, randomized, double-blind …

BACKGROUND: Spinal reconstructive surgery in adults can be associated with significant
blood loss, often requiring allogeneic blood transfusion. The objective of this randomized …

OBJECTIVE The purpose of this study was to investigate the effect of tranexamic acid (TXA)
compared to placebo in low-risk adult patients undergoing elective minor lumbar spine …

OBJECTIVE:: Tranexamic acid reduces blood loss and transfusion in on-pump coronary
artery bypass graft (CABG) surgery. Compared with on-pump, off-pump surgery is …