Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA
Proper DNA methylation patterns are essential for mammalian development and
differentiation. DNA methyltransferases (DNMTs) primarily establish and maintain global …
differentiation. DNA methyltransferases (DNMTs) primarily establish and maintain global …
Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro
AK Robertson, TM Geiman, UT Sankpal… - Biochemical and …, 2004 - Elsevier
DNA methylation is an epigenetic modification of the genome critical for numerous
processes, including transcriptional repression and maintenance of chromatin structure …
processes, including transcriptional repression and maintenance of chromatin structure …
De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases
H Gowher, CJ Stockdale, R Goyal, H Ferreira… - Biochemistry, 2005 - ACS Publications
In the cell, DNA is wrapped on histone octamers, which reduces its accessibility for DNA
interacting enzymes. We investigated de novo methylation of nucleosomal DNA in vitro and …
interacting enzymes. We investigated de novo methylation of nucleosomal DNA in vitro and …
Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance
How epigenetic information is propagated during somatic cell divisions is still unclear but is
absolutely critical for preserving gene expression patterns and cellular identity. Here we …
absolutely critical for preserving gene expression patterns and cellular identity. Here we …
Mammalian DNA methyltransferases show different subnuclear distributions
JB Margot, MC Cardoso… - Journal of cellular …, 2001 - Wiley Online Library
In mammalian cells, DNA methylation patterns are precisely maintained after DNA
replication with defined changes occurring during development. The major DNA …
replication with defined changes occurring during development. The major DNA …
Rethinking how DNA methylation patterns are maintained
DNA methylation patterns are set up early in mammalian development and are then copied
during the division of somatic cells. A long-established model for the maintenance of these …
during the division of somatic cells. A long-established model for the maintenance of these …
Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern
J Espada, E Ballestar, MF Fraga, A Villar-Garea… - Journal of Biological …, 2004 - ASBMB
DNA methyltransferase 1 (DNMT1) plays an essential role in murine development and is
thought to be the enzyme primarily responsible for maintenance of the global methylation …
thought to be the enzyme primarily responsible for maintenance of the global methylation …
Nucleosomes protect DNA from DNA methylation in vivo and in vitro
M Felle, H Hoffmeister, J Rothammer… - Nucleic acids …, 2011 - academic.oup.com
Positioned nucleosomes limit the access of proteins to DNA. However, the impact of
nucleosomes on DNA methylation in vitro and in vivo is poorly understood. Here, we …
nucleosomes on DNA methylation in vitro and in vivo is poorly understood. Here, we …
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation
The Dnmt3a DNA methyltransferase contains in its N-terminal part a PWWP domain that is
involved in chromatin targeting. Here, we have investigated the interaction of the PWWP …
involved in chromatin targeting. Here, we have investigated the interaction of the PWWP …
New concepts in DNA methylation
A Jeltsch, RZ Jurkowska - Trends in biochemical sciences, 2014 - cell.com
The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …