Certain dietary polyphenols, such as (−)-epigallocatechin 3-gallate (EGCG) from green tea
and genistein from soybean, have been demonstrated to inhibit DNA methyltransferases …

Epigenetic events constitute an important mechanism by which gene function is selectively
activated or inactivated. Since epigenetic events are susceptible to change they offer …

It is well established that aberrant gene regulation by epigenetic mechanisms can develop
as a result of pathological processes such as cancer. Methylation of CpG islands is an …

Hypermethylation of CpG islands in the promoter regions is an important mechanism to
silence the expression of many important genes in cancer. The hypermethylation status is …

Methylation of DNA occurs at cytosines within CpG (cytosine-guanine) dinucleotides and is
1 of several epigenetic mechanisms that serve to establish and maintain tissue-specific …

Epigenetic changes are inherited alterations in DNA that affect gene expression and
function without altering the DNA sequence. DNA methylation is one epigenetic process …

Cancer can take many years to develop from initiation to progression. The long period of
development might represent an opportunity to use multi-functional, multi-targeted …

DNA methylation is an important epigenetic mechanism of transcriptional control. DNA
methylation plays an essential role in maintaining cellular function, and changes in …

In the early 1930s, the group of Banting and Best showed that the choline moiety of lecithin
was responsible for the prevention of the fatty livers produced in pancreatectomized dogs …

Purpose: We have previously shown the reactivation of some methylation-silenced genes in
cancer cells by (−)-epigallocatechin-3-gallate, the major polyphenol from green tea. To …